Evidence map›Paper›PMID 28248449›Full record

ReviewTraffic (Copenhagen, Denmark)2017

Protein transport in growing and steady-state cilia.

Karl F Lechtreck, Julie C Van De Weghe, James Aaron Harris, Peiwei Liu

Abstract readReview
In one paragraph

Review in Traffic (Copenhagen, Denmark), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karl F LechtreckDepartment of Cellular Biology, University of Georgia, Athens, Georgia.
Julie C Van De WegheDepartment of Cellular Biology, University of Georgia, Athens, Georgia.
James Aaron HarrisDepartment of Cellular Biology, University of Georgia, Athens, Georgia.
Peiwei LiuDepartment of Cellular Biology, University of Georgia, Athens, Georgia.

Funding

Regulation of protein transport in ciliaR01GM110413 · NIGMS · UNIVERSITY OF GEORGIA · PI LECHTRECK, KARL · 2014 to 2022
$2.7M
NIGMS NIH HHS R01 GM110413
6 · The paper itself

Abstract

Cilia and eukaryotic flagella are threadlike cell extensions with motile and sensory functions. Their assembly requires intraflagellar transport (IFT), a bidirectional motor-driven transport of protein carriers along the axonemal microtubules. IFT moves ample amounts of structural proteins including tubulin into growing cilia likely explaining its critical role for assembly. IFT continues in non-growing cilia contributing to a variety of processes ranging from axonemal maintenance and the export of non-ciliary proteins to cell locomotion and ciliary signaling. Here, we discuss recent data on cues regulating the type, amount and timing of cargo transported by IFT. A regulation of IFT-cargo interactions is critical to establish, maintain and adjust ciliary length, protein composition and function.

Indexed as

AnimalsCiliaFlagellaHumansProteinsProtein TransportTubulinProteinsTubulindiffusionflagellaintraflagellar transportmicrotubule

Identifiers

PMID28248449
PMCPMC5389924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.