ArticleNature microbiology2017
A Mesh-Duox pathway regulates homeostasis in the insect gut.
Article in Nature microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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Who cites it
70 citing papers in PubMed, 130 citations in OpenAlex.
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- Reactive oxygen species-producing genes regulate mosquito midgut bacteria colonization, transcriptomic changes and cell repair.Communications biology · 2026Article
- From gatekeeper to target: MAPK cascades as control circuits at the insect-microbe interface.FEMS microbiology reviews · 2026Review
- Leveraging microbial ecology for mosquito-borne disease control.Trends in parasitology · 2025Review
- Age mosaic of gut epithelial cells prevents aging.Nature communications · 2025Article
- Fabrication of nanogels to improve the toxicity and persistence of cycloxaprid against Diaphorina citri, the vector of citrus huanglongbing.Journal of advanced research · 2025Article
- Protein landscape of the brush border membrane of first instar larvae of Frankliniella occidentalis, the western flower thrips.PloS one · 2025Article
- Differential RNAi efficacy of siRNA and dsRNA targeting key genes for pest control inFrontiers in insect science · 2025Article
- Characterization of larval gut microbiota of two endoparasitoid wasps associated with their common host,Microbiology spectrum · 2024Article
- Mosquito Gut Microbiota: A Review.Pathogens (Basel, Switzerland) · 2024Review
- Gut Microbiota MediateInternational journal of molecular sciences · 2024Article
- Ascarosides and Symbiotic Bacteria of Entomopathogenic Nematodes Regulate Host Immune Response inInsects · 2024Article
- Pathobiont and symbiont contribute to microbiota homeostasis through Malpighian tubules-gut countercurrent flow in Bactrocera dorsalis.The ISME journal · 2024Article
- Western diet consumption by host vertebrate promotes altered gene expression on Aedes aegypti reducing its lifespan and increasing fertility following blood feeding.Parasites & vectors · 2024Article
- Article
- The influence of the larval microbiome on susceptibility to Zika virus is mosquito genotype-dependent.PLoS pathogens · 2023Article
- Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Microbiota in disease-transmitting vectors.Nature reviews. Microbiology · 2023Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
The metazoan gut harbours complex communities of commensal and symbiotic bacterial microorganisms. The quantity and quality of these microorganisms fluctuate dynamically in response to physiological changes. The mechanisms that hosts have developed to respond to and manage such dynamic changes and maintain homeostasis remain largely unknown. Here, we identify a dual oxidase (Duox)-regulating pathway that contributes to maintaining homeostasis in the gut of both Aedes aegypti and Drosophila melanogaster. We show that a gut-membrane-associated protein, named Mesh, plays an important role in controlling the proliferation of gut bacteria by regulating Duox expression through an Arrestin-mediated MAPK JNK/ERK phosphorylation cascade. Expression of both Mesh and Duox is correlated with the gut bacterial microbiome, which, in mosquitoes, increases dramatically soon after a blood meal. Ablation of Mesh abolishes Duox induction, leading to an increase of the gut microbiome load. Our study reveals that the Mesh-mediated signalling pathway is a central homeostatic mechanism of the insect gut.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.