Evidence map›Paper›PMID 28248292›Full record

ArticleNature communications2017

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.

Eugene Y Chiang, Tianbo Li, Surinder Jeet, Ivan Peng, Juan Zhang, Wyne P Lee, Jason DeVoss, Patrick Caplazi, Jun Chen, Søren Warming and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

  1. miRNAs Related to Immune Checkpoint Inhibitor Response: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
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  18. Inhibition of KCancers · 2024
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Eugene Y ChiangDepartment of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Tianbo LiDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Surinder JeetDepartment of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Ivan PengDepartment of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Juan ZhangDepartment of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Wyne P LeeDepartment of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Jason DeVossDepartment of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Patrick CaplaziDepartment of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.ORCID 0000-0002-3411-1257
Jun ChenDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Søren WarmingDepartment of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
David H HackosDepartment of Neurobiology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Susmith MukundDepartment of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Christopher M KothDepartment of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Jane L GroganDepartment of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
ATUM (United States) · USGenesys (United States) · USInstitute for Structural Research · PLToxicologie, Pharmacologie et Signalisation Cellulaire · FRNeurological Surgery · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Voltage-gated Kv1.3 and Ca

Indexed as

Immunologic MemoryAnimalsEpitopesGene Knockdown TechniquesHumansImmunityIntermediate-Conductance Calcium-Activated Potassium ChannelsKv1.3 Potassium ChannelLymphocyte ActivationPhenotypePotassium Channel BlockersRatsRNA, Small InterferingT-LymphocytesEpitopesIntermediate-Conductance Calcium-Activated Potassium ChannelsKCNN4 protein, humanKcnn4 protein, ratKv1.3 Potassium ChannelPotassium Channel BlockersRNA, Small Interfering

Identifiers

PMID28248292
PMCPMC5337993
OpenAlexW2594633730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.