ReviewProteomes2016
Advances of Salivary Proteomics in Oral Squamous Cell Carcinoma (OSCC) Detection: An Update.
Review in Proteomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Spatially resolved proteomics provides insights into the normal-dysplasia-tumor continuum in oral squamous cell carcinoma.BMC oral health · 2026Article
- Early detection of oral squamous cell carcinoma using five tumor-associated autoantibodies and a Naive Bayes-based machine learning model.Scientific reports · 2026Article
- Diagnostic, Prognostic, and Predictive Molecular Biomarkers in Head and Neck Squamous Cell Carcinoma: A Comprehensive Review.Journal of clinical medicine · 2026Review
- Integrating lipid metabolite analysis with MRI-based transformer and radiomics for early and late stage prediction of oral squamous cell carcinoma.BMC cancer · 2024Article
- Current advances in noninvasive methods for the diagnosis of oral squamous cell carcinoma: a review.European journal of medical research · 2023Review
- Effect of ethanol extract fromOpen veterinary journal · 2023Article
- The Use of Salivary Levels of Matrix Metalloproteinases as an Adjuvant Method in the Early Diagnosis of Oral Squamous Cell Carcinoma: A Narrative Literature Review.Current issues in molecular biology · 2022Review
- High Expression of Heat Shock Protein Family D Member 1 Predicts Poor Prognosis of Esophageal Cancer.Journal of clinical medicine research · 2022Article
- Protein Profile of Human Saliva as a Predictive and Prognostic Tool for OSCC in Tamol Chewer's Population in Assam.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Salivary Osteopontin as a Potential Biomarker for Oral Mucositis.Metabolites · 2021Article
- Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.Cancer biomarkers : section A of Disease markers · 2021Article
- Salivary IL-6 mRNA is a Robust Biomarker in Oral Squamous Cell Carcinoma.Journal of clinical medicine · 2019Article
- Association between Salivary Fructosamine, Plasma Glycated Hemoglobin, and Plasma Glucose Levels among Type II Diabetes Mellitus and Nondiabetic Individuals-A Cross-sectional Study.European journal of dentistry · 2019Article
- Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia.International journal of molecular sciences · 2019Review
- HSPD1 repressed E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma.Scientific reports · 2019Article
- Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective.Frontiers in physiology · 2019Review
- Ki-67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma.Oncology letters · 2019Article
- miR-409-3p suppresses the proliferation, invasion and migration of tongue squamous cell carcinoma via targetingOncology letters · 2018Article
- Nanotechnology: a promising method for oral cancer detection and diagnosis.Journal of nanobiotechnology · 2018Review
- Salivary proteome profiling of oral squamous cell carcinoma in a Hungarian population.FEBS open bio · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral cancer refers to malignancies that have higher morbidity and mortality rates due to the late stage diagnosis and no early detection of a reliable diagnostic marker, while oral squamous cell carcinoma (OSCC) is amongst the world's top ten most common cancers. Diagnosis of cancer requires highly sensitive and specific diagnostic tools which can support untraceable hidden sites of OSCC, yet to be unleashed, for which plenty of biomarkers are identified; the most recommended biomarker detection medium for OSCC includes biological fluids, such as blood and saliva. Saliva holds a promising future in the search for new clinical biomarkers that are easily accessible, less complex, accurate, and cost effective as well as being a non-invasive technique to follow, by analysing the malignant cells' molecular pathology obtained from saliva through proteomic, genomic and transcriptomic approaches. However, protein biomarkers provide an immense potential for developing novel marker-based assays for oral cancer, hence this current review offers an overall focus on the discovery of a panel of candidates as salivary protein biomarkers, as well as the proteomic tools used for their identification and their significance in early oral cancer detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.