Evidence map›Paper›PMID 28248240›Full record

ArticleProteomes2016

Global Proteome Changes in Liver Tissue 6 Weeks after FOLFOX Treatment of Colorectal Cancer Liver Metastases.

Jozef Urdzik, Anna Vildhede, Jacek R Wiśniewski, Frans Duraj, Ulf Haglund, Per Artursson, Agneta Norén

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jozef UrdzikDepartment of Surgical Sciences, Uppsala University, SE-75185 Uppsala, Sweden. jozef.urdzik@surgsci.uu.se.
Anna VildhedeDepartment of Pharmacy, Uppsala University, SE-75237 Uppsala, Sweden. Anna.Vildhede@pfizer.com.
Jacek R WiśniewskiDepartment of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Martinsried 82152, Germany. jwisniew@biochem.mpg.de.
Frans DurajDepartment of Surgical Sciences, Uppsala University, SE-75185 Uppsala, Sweden. frans.duraj@surgsci.uu.se.
Ulf HaglundDepartment of Surgical Sciences, Uppsala University, SE-75185 Uppsala, Sweden. ulf.haglund@akademiska.se.
Per ArturssonDepartment of Pharmacy, Uppsala University, SE-75237 Uppsala, Sweden. per.artursson@farmaci.uu.se.
Agneta NorénDepartment of Surgical Sciences, Uppsala University, SE-75185 Uppsala, Sweden. agneta.noren@akademiska.se.
Uppsala University · SEMax Planck Institute of Biochemistry · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Oxaliplatin-based chemotherapy for colorectal cancer liver metastasis is associated with sinusoidal injury of liver parenchyma. The effects of oxaliplatin-induced liver injury on the protein level remain unknown. (2) Protein expression in liver tissue was analyzed-from eight patients treated with FOLFOX (combination of fluorouracil, leucovorin, and oxaliplatin) and seven controls-by label-free liquid chromatography mass spectrometry. Recursive feature elimination-support vector machine and Welch

Indexed as

DNA replicationinnate immune responselabel-free liquid chromatography mass spectrometryminichromosome maintenance complexoxaliplatin-based chemotherapyprotein expressionrecovery of liver injury

Identifiers

PMID28248240
PMCPMC5260963
OpenAlexW342727112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.