ArticleJournal of clinical laboratory analysis2018
Prognostic significance of long noncoding RNA Z38 as a candidate biomarker in breast cancer.
Article in Journal of clinical laboratory analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Long Noncoding RNA Serve as a Potential Predictive Biomarker for Breast Cancer: A Meta-Analysis.BioMed research international · 2020Pooled it
- Review
- KCNQ1OT1 affects cell proliferation, invasion, and migration through a miR-34a / Notch3 axis in breast cancer.Environmental science and pollution research international · 2022Article
- Coding roles of long non-coding RNAs in breast cancer: Emerging molecular diagnostic biomarkers and potential therapeutic targets with special reference to chemotherapy resistance.Frontiers in genetics · 2022Review
- LncRNAs AK058003 and MVIH Overexpression in the Blood Samples of Iranian Breast Cancer Patients.Iranian biomedical journal · 2021Article
- Long non-coding RNA regulation of TRAIL in breast cancer: A tangle of non-coding threads.Oncology letters · 2020Review
- Function and regulation annotation of up-regulated long non-coding RNA LINC01234 in gastric cancer.Journal of clinical laboratory analysis · 2020Article
- Expression of the long noncoding RNA RP11-169D4.1-001 in Hypopharyngeal Squamous cell carcinoma tissue and its clinical significance.Journal of clinical laboratory analysis · 2020Article
- Global expression profiling of metabolic pathway-related lncRNAs in human gastric cancer and the identification of RP11-555H23.1 as a new diagnostic biomarker.Journal of clinical laboratory analysis · 2019Article
- Article
- Long noncoding RNA Z38 promotes cell proliferation and metastasis and inhibits cell apoptosis in human gastric cancer.Oncology letters · 2018Article
- Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases.Journal of molecular medicine (Berlin, Germany) · 2018Review
- The regulatory roles of lncRNAs in the process of breast cancer invasion and metastasis.Bioscience reports · 2018Review
- The Impact of lncRNA Dysregulation on Clinicopathology and Survival of Breast Cancer: A Systematic Review and Meta-analysis.Molecular therapy. Nucleic acids · 2018Article
- Identification and functional annotation of metabolism-associated lncRNAs and their related protein-coding genes in gastric cancer.Molecular genetics & genomic medicine · 2018Article
- Long non-coding RNA AC026166.2-001 inhibits cell proliferation and migration in laryngeal squamous cell carcinoma by regulating the miR-24-3p/p27 axis.Scientific reports · 2018Article
- Prognostic significance of long noncoding RNA Z38 as a candidate biomarker in breast cancer.Journal of clinical laboratory analysis · 2018Article
- Role of DiGeorge syndrome critical region gene 9, a long noncoding RNA, in gastric cancer.OncoTargets and therapy · 2018Article
- Long intergenic non-protein coding RNA 1006 used as a potential novel biomarker of gastric cancer.Cancer biomarkers : section A of Disease markers · 2017Article
- Evaluation on the diagnostic and prognostic values of long non-coding RNA BLACAT1 in common types of human cancer.Molecular cancer · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong noncoding RNA (lncRNA) Z38 has been shown to promote cell proliferation and tumorigenesis in breast cancer. However, expression pattern and prognostic value of lncRNA Z38 in breast cancer patients remain elusive.
methodsThe expression levels of SPRY4-IT1 in 110 self-paired specimens of breast cancer and adjacent normal breast tissues were measured by quantitative real-time PCR (qRT-PCR), and its correlation with overall survival of patients with breast cancer was further statistically analyzed.
resultsCompared with normal breast tissues, Z38 was upregulated in breast cancer tissues. Furthermore, of 110 breast cancer patients, high Z38 expression was significantly associated with tumor-node-metastasis stage and lymph node metastasis. Further analysis using the Cox regression model revealed that Z38 expression was an independent prognostic factor of overall survival in patients with breast cancer (hazard ratio=4.74, 95% confidence interval 2.41-9.32). The nomogram presents a good prediction of the probability of overall survival of breast cancer patients (c-index: 0.792), and its predictive efficiency was further confirmed by the calibration curve.
conclusionOur data highlighted the potential of lncRNA Z38 as novel candidate biomarker to identify patients with breast cancer at high risk of tumor death.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.