Evidence map›Paper›PMID 28247896›Full record

ArticleNanoscale2017

Surfactant-stripped naphthalocyanines for multimodal tumor theranostics with upconversion guidance cream.

Yumiao Zhang, Hao Hong, Boyang Sun, Kevin Carter, Yiru Qin, Wei Wei, Depeng Wang, Mansik Jeon, Jumin Geng, Robert J Nickles and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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  6. A ratiometric fluorescent nanoprobe for ultrafast imaging of peroxynitrite in living cells.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Yumiao ZhangDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu and Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Hao HongCenter for Molecular Imaging, University of Michigan, Ann Arbor, Michigan 48109, USA.
Boyang SunDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu and Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Kevin CarterDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu.
Yiru QinDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu.
Wei WeiInstitute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Depeng WangDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu.
Mansik JeonSchool of Electronics Engineering, College of IT Engineering, Kyungpook National University, 702701, Korea.
Jumin GengDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu.
Robert J NicklesDepartment of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Guanying ChenInstitute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA and School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150001, People's Republic of China.ORCID http://orcid.org/0000-0002-4789-1176
Paras N PrasadInstitute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Chulhong KimCreative IT Engineering, Pohang University of Science and Technology, 790784, Korea.
Jun XiaDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu.
Weibo CaiDepartment of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu and Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.ORCID http://orcid.org/0000-0002-9052-884X
University at Buffalo, State University of New York · USUniversity of Wisconsin–Madison · USHarbin Institute of Technology · CNKyungpook National University · KRPohang University of Science and Technology · KRUniversity of Michigan · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR LightDP5OD017898 · OD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2017
$1.9M
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NIH HHS DP5 OD017898
6 · The paper itself

Abstract

Surfactant-stripped, nanoformulated naphthalocyanines (nanonaps) can be formed with Pluronic F127 and low temperature membrane processing, resulting in dispersed frozen micelles with extreme contrast in the near infrared region. Here, we demonstrate that nanonaps can be used for multifunctional cancer theranostics. This includes lymphatic mapping and whole tumor photoacoustic imaging following intradermal or intravenous injection in rodents. Without further modification, pre-formed nanonaps were used for positron emission tomography and passively accumulated in subcutaneous murine tumors. Because the nanonaps used absorb light beyond the visible range, a topical upconversion skin cream was developed for anti-tumor photothermal therapy with laser placement that can be guided by the naked eye.

Indexed as

PhototherapyTheranostic NanomedicineAnimalsFemaleMiceMice, Inbred BALB CMice, Inbred ICRNanoparticlesNeoplasms, ExperimentalSurface-Active AgentsTissue DistributionSurface-Active Agents

Identifiers

PMID28247896
PMCPMC5435468
OpenAlexW2588530269

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.