Evidence map›Paper›PMID 28247847›Full record

Observational studyThe American journal of cardiology2017

Risk Estimates for Atherosclerotic Cardiovascular Disease in Adults With Congenital Heart Disease.

George K Lui, Ian S Rogers, Victoria Y Ding, Haley K Hedlin, Kirstie MacMillen, David J Maron, Christy Sillman, Anitra Romfh, Tara C Dade, Christiane Haeffele and 4 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The American journal of cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Overweight and Obesity in Patients with Congenital Heart Disease: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Coronary artery disease in adults with congenital heart disease.International journal of cardiology. Congenital heart disease · 2023
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Aging, Cardiovascular Risk, and SHBG Levels in Men and Women From the General Population.The Journal of clinical endocrinology and metabolism · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

George K LuiDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, California; Division of Pediatric Cardiology, Department of Pediatrics, Stanford University, Palo Alto, California; Stanford Children's Health Research Institute, Palo Alto, California; Stanford Cardiovascular Institute, Palo Alto, California. Electronic address: glui@stanford.edu.
Ian S RogersDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, California; Division of Pediatric Cardiology, Department of Pediatrics, Stanford University, Palo Alto, California; Stanford Cardiovascular Institute, Palo Alto, California.
Victoria Y DingQuantitative Sciences Unit, Department of Medicine, Stanford University, Palo Alto, California.
Haley K HedlinQuantitative Sciences Unit, Department of Medicine, Stanford University, Palo Alto, California.
Kirstie MacMillenStanford University, Spectrum Child Health, Center for Clinical and Translational Research and Education, Palo Alto, California.
David J MaronDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, California.
Christy SillmanLucile Packard Children's Hospital, Children's Heart Center, Palo Alto, California.
Anitra RomfhDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, California; Division of Pediatric Cardiology, Department of Pediatrics, Stanford University, Palo Alto, California.
Tara C DadeStanford Health Care, Palo Alto, California.
Christiane HaeffeleDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, California; Division of Pediatric Cardiology, Department of Pediatrics, Stanford University, Palo Alto, California.
Stafford R GradyDivision of Pediatric Cardiology, Department of Pediatrics, Stanford University, Palo Alto, California.
Doff B McElhinneyDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, California.
Daniel J MurphyDivision of Pediatric Cardiology, Department of Pediatrics, Stanford University, Palo Alto, California.
Susan M FernandesDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, California; Division of Pediatric Cardiology, Department of Pediatrics, Stanford University, Palo Alto, California; Stanford Children's Health Research Institute, Palo Alto, California; Stanford Cardiovascular Institute, Palo Alto, California.
Stanford University · USPalo Alto University · USLucile Packard Children's Hospital · USStanford Health Care · US

Funding

Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
NCRR NIH HHS UL1 RR025744
6 · The paper itself

Abstract

The adult with congenital heart disease (CHD) is at risk of developing atherosclerotic cardiovascular disease (ASCVD). We performed a cross-sectional study to describe established ASCVD risk factors and estimate 10-year and lifetime risk of ASCVD in adults over age 18 with CHD of moderate or great complexity using 3 validated risk assessment tools-the Framingham Study Cardiovascular Disease Risk Assessment, the Reynolds Risk Score, and the ASCVD Risk Estimator. We obtained extensive clinical and survey data on 178 enrolled patients, with average age 37.1 ± 12.6 years, 51% men. At least 1 modifiable ASCVD risk factor was present in 70%; the 2 most common were overweight/obesity (53%) and systemic hypertension (24%). Laboratory data were available in 103 of the 178 patients. Abnormal levels of glycated hemoglobin, high-sensitivity C-reactive protein, and high-density lipoprotein were each found in around 30% of patients. The 10-year ASCVD predicted risk using all 3 tools was relatively low (i.e., at least 90% of patients <10% risk), yet the median estimated lifetime risk was 36%. In conclusion, ASCVD risk factors are prevalent in adults with CHD. The risk estimation tools suggest that this population is particularly vulnerable to ASCVD with aging and should undergo guideline-based screening and management of modifiable risk factors.

Indexed as

AdolescentAdultAnthropometryAtherosclerosisCaliforniaChildCoronary Artery DiseaseCross-Sectional StudiesFemaleHeart Defects, CongenitalHumansMaleRisk AssessmentRisk Factors

Identifiers

PMID28247847
PMCPMC5334785
OpenAlexW2523842142

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.