ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2017
Electronic patient-reported outcomes and toxicities during radiotherapy for head-and-neck cancer.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Electronic patient-reported outcome systems and capabilities in cancer care: a systematic review.Frontiers in digital health · 2025Pooled it
- Advancing patient-centered cancer care: a systematic review of electronic patient-reported outcome measures.Frontiers in rehabilitation sciences · 2024Pooled it
- Systematic Review of Normal Tissue Complication Models Relevant to Standard Fractionation Radiation Therapy of the Head and Neck Region Published After the QUANTEC Reports.International journal of radiation oncology, biology, physics · 2018Pooled it
- Optimized Dosing of Regorafenib in Patients With Metastatic Colorectal Cancer: A Practical Guide for Oncologists, Advanced Practice Providers, and Pharmacists.Journal of the advanced practitioner in oncology · 2025Review
- Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal.Cancers · 2024Article
- The impact of palliative radiotherapy on health-related quality of life in patients with head and neck cancer - Results of a multicenter prospective cohort study.Clinical and translational radiation oncology · 2023Article
- Patient-reported outcomes and complications during head and neck cancer radiotherapy before versus during the COVID-19 pandemic.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- How is quality of life defined and assessed in published research?Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Review
- A review of the barriers to using Patient-Reported Outcomes (PROs) and Patient-Reported Outcome Measures (PROMs) in routine cancer care.Journal of medical radiation sciences · 2021Review
- Patient-reported outcome measures in patients undergoing radiotherapy for head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Patient-reported quality-of-life outcomes in relation to provider-assessed adverse events during head and neck radiotherapy.Journal of patient-reported outcomes · 2020Article
- Patient-reported financial toxicity and adverse medical consequences in head and neck cancer.Oral oncology · 2020Article
- Using PROMs to guide patients and practitioners through the head and neck cancer journey.Patient related outcome measures · 2017Review
- Baseline Quality of Life is a Strong and Independent Prognostic Factor for Overall Survival in Metastatic Colorectal Cancer.Cancer control : journal of the Moffitt Cancer CenterArticle
- Review
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Authors and funding
6 authors.
Funding
Abstract
purposeTo characterize quality of life (QOL) using real-time, electronic patient-reported outcomes (ePROs) and to evaluate adverse events (AEs) and supportive care during head-and-neck radiotherapy (RT) and concurrent chemoradiotherapy (CCRT).
methodsSixty-five patients undergoing head-and-neck RT completed electronic, real-time, 12-item linear analog self-assessments (LASA) at baseline, before biweekly appointments, and at the last week of RT. Changes in QOL domains between time points were calculated. Clinical data were collected from the institutional medical record. AEs were recorded at the same time points as the LASA and graded.
resultsDuring head-and-neck RT, most patients had clinically meaningful decreases in all QOL domains except level of support, financial concerns, and legal concerns. QOL domains with the most prevalent, clinically meaningful decreases were fatigue (75.4% of patients; 95% CI, 62.9-84.9%), social activity (70.8%; 95% CI, 58.0-81.1%), and overall QOL (70.8%; 95% CI, 58.0-81.1%). All patients had grade 2 AEs; 35.4% had grade 3 (50.0%, CCRT; 12.0%, RT; P = .002). Weight loss averaged 5.5 kg (6.9 kg, CCRT; 2.8 kg, RT; P < .001). Intravenous hydration was needed in 52.3% (77.5%, CCRT; 12.0%, RT; P < .001); feeding tube placement 40.0% (57.5%, CCRT; 12.0%, RT; P = .001); emergency department visits without hospitalization, 10.8%; and emergent hospitalization, 27.7% (37.5%, CCRT; 12.0%, RT; P = .04).
conclusionsHead-and-neck RT, particularly CCRT, negatively impacts patients' overall QOL, social activity, and fatigue, with frequent grade 3 AEs, weight loss, intravenous hydration, feeding tube placement, ED visits, and hospitalization. Real-time ePROs allow providers to monitor QOL at multiple time points during RT, potentially allowing early intervention to improve QOL and mitigate AEs.
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