ArticleHead and neck pathology2017
Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Mucosal Melanomas.
Article in Head and neck pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Oral Amelanotic Melanoma: A Systematic Review of Case Reports and Case Series.Head and neck pathology · 2022Pooled it
- Hypomelanotic melanoma of the mandibular gingiva: a case report and literature review.BMC oral health · 2026Review
- Mucosal melanoma: clinicopathological, molecular and prognostic features in a retrospective cohort.Virchows Archiv : an international journal of pathology · 2026Article
- Sinonasal Mucosal Melanoma Survival Outcomes, Recurrence Patterns, and Prognostic Factors: A Systematic Literature Review and Meta-analysis of Publications after 2000.Journal of neurological surgery. Part B, Skull base · 2025Article
- Pigmented Lesions of the Oral Mucosa: Clinical Presentation, Histology, and Recommendations for Management.American journal of clinical dermatology · 2025Review
- Survival and prognostic factors in mucosal melanomas of the oral cavity: A meta-analysis.Journal of dental research, dental clinics, dental prospects · 2025Review
- Primary Intraosseous Squamous Cell Carcinoma of the Mandible: A Rare and Challenging Case.Cureus · 2025Article
- Primary Sinonasal Mucosal Melanoma: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma.Cancer reports (Hoboken, N.J.) · 2025Article
- Malignant Melanoma of the Tongue: A Scoping Review.Life (Basel, Switzerland) · 2025Review
- Missed diagnosis of primary intraosseous squamous cell carcinoma - A case report.Bioinformation · 2025Article
- Case Report: S100-negative primary anorectal melanoma with elevated Ki67: a case for biology-driven radical resection despite early radiological staging.Frontiers in oncology · 2025Article
- Amelanotic Melanoma: A Rare Sinonasal Malignancy.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review.Cancers · 2024Review
- Clinicopathological Features of 26 Intraoral Polymorphous Adenocarcinomas from a Single Brazilian Institution.Head and neck pathology · 2024Article
- Challenges in the Diagnosis and Treatment of Oral Amelanotic Malignant Melanoma: A Case Report.Cureus · 2024Article
- Diagnosing Cutaneous Melanocytic Tumors in the Molecular Era: Updates and Review of Literature.Dermatopathology (Basel, Switzerland) · 2024Review
- Small Round Blue Cell Tumours of the Sinonasal Area: Our 5 year Experience in a Tertiary Care Centre in India.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Amelanotic Melanoma: A Great Masquerader.Journal of laboratory physicians · 2023Article
- Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B.Histopathology · 2023Article
Corrections and comments
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Funding
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Abstract
The updated edition of The World Health Organization Classification of Tumours of the Head and Neck includes discussions on mucosal melanoma of both the sinonasal and oral cavity. Since the prior edition, sinonasal origin is now recognized as the most common site of occurrence of mucosal melanoma in the head and neck (66%) with oral cavity representing 25% of cases. Histologic features of mucosal melanomas vary widely from spindled, epithelioid, and pleomorphic to rhabdoid, plasmacytoid and undifferentiated. Additionally, mucosal melanomas are commonly amelanotic (or minimal pigmentation) (~50%) leading to overlapping features and diagnostic challenges in differentiating mucosal melanomas from other small cell/undifferentiated sinonasal tumors. Since the last edition, formal staging of head and neck mucosal melanomas was added to the American Joint Committee on Cancer entities, though the traditional histologic features that have prognostic significance in cutaneous melanomas fail to stratify mucosal melanomas (i.e. tumor thickness, ulceration). Interestingly, while melanomas of all sites are a malignancy derived from melanocytes, mucosal melanomas are now recognized to have distinct molecular alterations compared to cutaneous or uveal melanomas. BRAF V600E mutations are rare (<6%) in mucosally derived melanomas compared to a rate of 50% in cutaneous melanomas. CD117 (C-Kit) mutations are the most common alteration encountered (~25%) in mucosal sites with potential therapeutic targetability. The recognition of the distinct genetic changes in this subgroup of melanomas means that therapy advances in cutaneous melanomas may not translate to head and neck mucosal melanomas and clinical trials specific to this subgroup of patients are needed.
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