ArticleMolecular and cellular biochemistry2017
Pyruvate antioxidant roles in human fibroblasts and embryonic stem cells.
Article in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Genetically predicted 486 blood metabolites in relation to risk of colorectal cancer: A Mendelian randomization study.Cancer medicine · 2023Pooled it
- Effect of Co-Exposure to Temperature and Fine Particulate Matter on Metabolomic and Immune Processes among Chinese Women of Childbearing Age.Environment & health (Washington, D.C.) · 2026Article
- The activation of the metabolic oxaloacetate-pyruvate axis restores influenza A virus replication during impaired glycolysis.Virology journal · 2026Article
- CNOT2 /c-Myc/STAT3 signaling is critically involved in glycolysis mediated apoptosis of benzyl isothiocyanate in hepatocellular carcinoma.Scientific reports · 2026Article
- Circular economy strategies in biodesulfurization: bridging sustainability and sulfur recovery.Archives of microbiology · 2025Review
- Exogenous Pyruvate in Defense Against Human-Exposure Toxicants: A Review of In Vitro and In Vivo Evidence.International journal of molecular sciences · 2025Review
- The role of sodium pyruvate in mitigating the cytotoxic effects of vanadium on CHO-K1 cells.Scientific reports · 2025Article
- Article
- Measurement of Intracellular Reactive Oxygen Species During Adipogenesis.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Reactive oxygen species in biological systems: Pathways, associated diseases, and potential inhibitors-A review.Food science & nutrition · 2024Review
- Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis.Journal of inflammation (London, England) · 2023Article
- UVA-induced metabolic changes in non-malignant skin cells and the potential role of pyruvate as antioxidant.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- Nutritional requirements of human induced pluripotent stem cells.Stem cell reports · 2023Article
- Articular Cartilage Chondroprogenitors: Isolation and Directed Differentiation.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Article
- Effects of Sodium Pyruvate on Vanadyl Sulphate-Induced Reactive Species Generation and Mitochondrial Destabilisation in CHO-K1 Cells.Antioxidants (Basel, Switzerland) · 2022Article
- The induction of natural competence adapts staphylococcal metabolism to infection.Nature communications · 2022Article
- Targeting Oxidative Stress: Novel Coumarin-Based Inverse Agonists of GPR55.International journal of molecular sciences · 2021Article
- Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions.Scientific reports · 2021Article
- Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis.NPJ biofilms and microbiomes · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress has been related to multiple diseases, especially during early embryonic development, when environmental alterations can lead to long-term deleterious effects. In vitro studies of oxidative stress have been mainly focused on somatic cells, but embryonic stem cells (ESCs) represent a promising model of early embryonic development as they are the in vitro equivalent to pluripotent cells in the embryo. Human fibroblasts and ESCs were exposed to different pro-oxidant agents (hydrogen peroxide, tert-butyl hydroperoxide (TBHP), and rotenone) and antioxidants (sodium pyruvate, N-acetylcysteine, Trolox, and sodium selenite) during a 72 h oxidative stress treatment. Then, cell viability, oxidative stress, mitochondrial activity, and gene expression were analyzed, focusing on the antioxidant effect of pyruvate. Pyruvate protected both somatic and pluripotent cells against different pro-oxidant agents, showing strong ROS scavenging capacity, protecting mitochondrial membrane potential, and regulating gene expression and cell metabolism through different mechanisms in fibroblasts and ESCs. In fibroblasts, pyruvate avoided NFKβ nuclear translocation and the upregulation of genes related to the oxidative stress response, while in ESCs pyruvate stimulated the expression of genes involved in anaerobic glycolysis. Fibroblasts and ESCs reacted in different ways to oxidative stress and antioxidant treatment, and pyruvate was the most complete antioxidant, protecting both cell types at different levels.
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