ReviewCurrent genetics2017
Quorum sensing by farnesol revisited.
Review in Current genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Quorum Signaling Molecules: Interactions Between Plants and Associated Pathogens.International journal of molecular sciences · 2025Review
- Review
- Exploring the female genital tract mycobiome in young South African women using metaproteomics.Microbiome · 2025Article
- Evaluation of the Antimicrobial Activity of Geraniol and Selected Geraniol Transformation Products against Gram-Positive Bacteria.Molecules (Basel, Switzerland) · 2024Article
- Studying mixed-species biofilms of Candida albicans and Staphylococcus aureus using evolutionary game theory.PloS one · 2024Article
- Augmented Enterocyte Damage DuringFrontiers in cellular and infection microbiology · 2022Article
- Review
- Adapting to survive: How Candida overcomes host-imposed constraints during human colonization.PLoS pathogens · 2020Review
- UnravelingFrontiers in cellular and infection microbiology · 2020Article
- Farnesol, a Quorum-Sensing Molecule ofCells · 2019Article
- Diversity of the Rap-Phr quorum-sensing systems in the Bacillus cereus group.Current genetics · 2019Article
- Pathogenetic Impact of Bacterial-Fungal Interactions.Microorganisms · 2019Review
- Physiological and Transcriptional Responses of Candida parapsilosis to Exogenous Tyrosol.Applied and environmental microbiology · 2019Article
- Systematic analysis of protein expression in Candida albicans exposed to farnesol.Chinese medical journal · 2019Article
- Mechanisms of RsaL mediated tolerance to ciprofloxacin and carbenicillin in Pseudomonas aeruginosa.Current genetics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Quorum sensing, a form of molecular communication in microbial communities, is relatively well studied in bacterial species, but poorly understood in fungi. Farnesol, a quorum sensing molecule secreted by the opportunistic human pathogenic fungus Candida albicans, was the first quorum sensing molecule described in a eukaryotic organism. However, despite considerable research efforts and advances in recent years, the mechanisms behind its action remain largely elusive. Only recently, we showed that deletion of the C. albicans gene EED1 (eed1Δ), which is essential for hyphal maintenance, resulted in both increased farnesol production and hypersensitivity to farnesol, providing a link between farnesol signaling and elongated hyphal growth. This finding raised several questions concerning farnesol signaling. In this short review we use the unique phenotype of the eed1Δ mutant to summarize current hypotheses and to speculate on possible mechanisms of quorum sensing in C. albicans and its implication in fungus-host interaction, by drawing comparisons to comparatively well-studied quorum sensing systems in bacteria.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.