Evidence map›Paper›PMID 28246881›Full record

ArticleCancer immunology, immunotherapy : CII2017

Novel B7-H4-mediated crosstalk between human non-Hodgkin lymphoma cells and tumor-associated macrophages leads to immune evasion via secretion of IL-6 and IL-10.

Fengyuan Che, Xueyuan Heng, Haiyan Zhang, Quanping Su, Baoxue Zhang, Yanying Chen, Zhaohong Zhang, Yifeng Du, Lijuan Wang

Open access · greenAbstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. The value of serum IL-4 to predict the survival of MDS patients.European journal of medical research · 2023
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Resistance to Immunotherapy: Mechanisms and Means for Overcoming.Advances in experimental medicine and biology · 2021
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Functional macrophages and gastrointestinal disorders.World journal of gastroenterology · 2018
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fengyuan CheCentral Laboratory, Linyi People's Hospital, Shandong University, Linyi, Shandong, China.
Xueyuan HengDepartment of Neurosurgery, Linyi People's Hospital, Shandong University, Linyi, Shandong, China.
Haiyan ZhangDepartment of Hematology, Linyi People's Hospital, Shandong University, No. 27 Jiefang Road, Lanshan District, Linyi, Shandong, China.
Quanping SuCentral Laboratory, Linyi People's Hospital, Shandong University, Linyi, Shandong, China.
Baoxue ZhangHematology Laboratory, Linyi People's Hospital, Shandong University, Linyi, Shandong, China.
Yanying ChenHematology Laboratory, Linyi People's Hospital, Shandong University, Linyi, Shandong, China.
Zhaohong ZhangHematology Laboratory, Linyi People's Hospital, Shandong University, Linyi, Shandong, China.
Yifeng DuDepartment of Neurology, Shandong Provincial Hospital, Shandong University, 44 Wenhua West Road, Jinan, Shandong, China. duyf69@163.com.
Lijuan WangDepartment of Hematology, Linyi People's Hospital, Shandong University, No. 27 Jiefang Road, Lanshan District, Linyi, Shandong, China. wanglj730@163.com.
Linyi People's Hospital · CNShandong University · CNShandong Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-Hodgkin lymphoma (NHL) is an incurable lymphoproliferative cancer, and patients with NHL have a poor prognosis. The present study explored the regulatory mechanism of expression and possible roles of the immunosuppressive B7-H4 molecule in human NHL. For functional studies, NHL-reactive T cell lines were generated via the isolation of allogeneic CD3

Indexed as

Tumor EscapeCell CommunicationHumansInterleukin-10Interleukin-6Lymphoma, Non-HodgkinMacrophagesT-Lymphocytes, RegulatoryTumor Cells, CulturedV-Set Domain-Containing T-Cell Activation Inhibitor 1IL10 protein, humanIL6 protein, humanInterleukin-10Interleukin-6V-Set Domain-Containing T-Cell Activation Inhibitor 1VTCN1 protein, humanB7-H4IL-10IL-6Immune evasionNon-Hodgkin lymphomaTumor-associated macrophages

Identifiers

PMID28246881
PMCPMC11028477
OpenAlexW2594317690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.