ArticleScience advances2017
Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
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Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
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Who cites it
44 citing papers in PubMed, 72 citations in OpenAlex.
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- Structure of human glycoprotein 2 reveals mechanisms underlying filament formation and adaption to proteolytic environment in the digestive tract.PLoS biology · 2025Article
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- Structural basis for adhesin secretion by the outer-membrane usher in type 1 pili.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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- Nature of the Interaction of Alpha-D-Mannose and Escherichia coli Bacteria, and Implications for its Regulatory Classification. A Delphi Panel European Consensus Based on Chemistry and Legal Evidence.Therapeutic innovation & regulatory science · 2023Article
- Screening of antigenic epitopes related to the adhesion of the avian Escherichia coli Type 1 Fimbrial Agglutinin Domain.BMC veterinary research · 2023Article
- Binding site plasticity regulation of the FimH catch-bond mechanism.Biophysical journal · 2023Article
- Glycomimetics for the inhibition and modulation of lectins.Chemical Society reviews · 2023Review
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Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Vasilios KalasCenter for Women's Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9685-4139
Jerome S PinknerCenter for Women's Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-7389-7440
Thomas J HannanCenter for Women's Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-0498-8231
Michael E HibbingCenter for Women's Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-0072-6210
Karen W DodsonCenter for Women's Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Alex S HolehouseDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.ORCID 0000-0002-4155-5729
Hao ZhangDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
Niraj H ToliaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael L GrossDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.ORCID 0000-0003-1159-4636
Rohit V PappuDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
James JanetkaDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
Scott J HultgrenCenter for Women's Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Washington University in St. Louis · US
Funding
Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8MMOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8MPATHOGENIC FIBER FORMATION IN BACTERIA: STRUCTURAL BASISR01AI048689 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2001 to 2020
$7.6MCHAPERONE-ASSISTED PILI ASSEMBLY IN PATHOGENIC E. COLIR01AI029549 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J., YUAN, PENG · 1991 to 2023
$5.7MPathogenic Fiber Formation in Bacteria: Structural BasisR37AI048689 · NIAID · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 2021 to 2026
$2.9MNIAID NIH HHS R01 AI029549NIAID NIH HHS R37 AI048689NIAID NIH HHS U01 AI095542NIDDK NIH HHS R01 DK051406
Abstract
Positive selection in the two-domain type 1 pilus adhesin FimH enhances
Indexed as
Adhesins, Escherichia coliEscherichia coliEscherichia coli InfectionsFimbriae ProteinsUrinary BladderUrinary Tract InfectionsAnimalsFemaleHost-Parasite InteractionsMiceProtein DomainsAdhesins, Escherichia coliFimbriae ProteinsfimH protein, E coliadhesinBladder epitheliumChaperone usher piliEscherichia coliFimHMolecular Tetheringpositive selectionProtein AllosteryProtein ConformationUrinary tract infection
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.