ArticleWorld journal of gastroenterology2017
Eosinophilic cholangitis is a potentially underdiagnosed etiology in indeterminate biliary stricture.
Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Elevated serum IgG4 and eosinophilia in a persistent indeterminate biliary stricture with high-risk features: a case report.Frontiers in medicine · 2026Article
- Secondary sclerosing cholangitis: contemporary etiologies, diagnostic pathways, and treatment strategies for clinicians: a narrative review.Translational gastroenterology and hepatology · 2026Review
- Mixed cholangiopathy with eosinophilic and autoimmune features: a case report.Journal of medical case reports · 2025Article
- Rare Presentation of Eosinophilic Cholangitis in a 32-Year-Old Man.ACG case reports journal · 2025Article
- A case of eosinophilic cholangitis without bile duct stenosis diagnosed by bile duct biopsy.DEN open · 2022Article
- A case of eosinophilic cholangiopathy mimicking cholangiocarcinoma.Clinical journal of gastroenterology · 2021Article
- A case of juvenile eosinophilic cholangitis: Rapid peripheral blood hypereosinophilia after admission leading to diagnosis.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- [Differential diagnoses of biliary tract diseases : Computed tomography and magnetic resonance imaging].Der Radiologe · 2019Review
- Eosinophilic cholangitis treatment with budesonide.World journal of hepatology · 2017Article
- Cholangitis: Diagnosis, Treatment and Prognosis.Journal of clinical and translational hepatology · 2017Review
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9 authors at 2 institutions in 1 country.
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Abstract
aimTo investigate presence and extent of eosinophilic cholangitis (EC) as well as IgG4-related disease in patients with indeterminate biliary stricture (IBS).
methodsAll patients with diagnosis of sclerosing cholangitis (SC) and histopathological samples such as biopsies or surgical specimens at University Hospital Frankfurt from 2005-2015 were included. Histopathological diagnoses as well as further clinical course were reviewed. Tissue samples of patients without definite diagnosis after complete diagnostic work-up were reviewed regarding presence of eosinophilic infiltration and IgG4 positive plasma cells. Eosinophilic infiltration was as well assessed in a control group of liver transplant donors and patients with primary sclerosing cholangitis.
resultsone hundred and thirty-five patients with SC were included. In 10/135 (13.5%) patients, no potential cause of IBS could be identified after complete diagnostic work-up and further clinical course. After histopathological review, a post-hoc diagnosis of EC was established in three patients resulting in a prevalence of 2.2% (3/135) of all patients with SC as well as 30% (3/10) of patients, where no cause of IBS was identified. 2/3 patients with post-hoc diagnosis of EC underwent surgical resection with suspicion for malignancy. Diagnosis of IgG4-related cholangitis was observed in 7/135 patients (5.1%), whereas 3 cases were discovered in post-hoc analysis. 6/7 cases with IgG4-related cholangitis (85.7%) presented with eosinophilic infiltration in addition to IgG4 positive plasma cells. There was no patient with eosinophilic infiltration in the control group of liver transplant donors (
conclusionEC is an underdiagnosed benign etiology of SC and IBS, which has to be considered in differential diagnosis of IBS.
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