ReviewWorld journal of gastroenterology2017
Lymphocytic esophagitis: Still an enigma a decade later.
Review in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Clinical, endoscopic, and histologic characteristics of lymphocytic esophagitis: a systematic review.Esophagus : official journal of the Japan Esophageal Society · 2019Pooled it
- Article
- Article
- Esophageal Lichen Planus-Contemporary Insights and Emerging Trends.Biomedicines · 2025Review
- Odynophagia and Retrosternal Pain Are Common in Eosinophilic Esophagitis and Associated with an Increased Overall Symptom Severity.Digestive diseases and sciences · 2024Article
- Article
- Lymphocytic oesophagitis: diagnosis and management.Clinical medicine (London, England) · 2023Review
- Article
- Eosinophilic Esophagitis beyond Eosinophils - an Emerging Phenomenon Overlapping with Eosinophilic Esophagitis: Collegium Internationale Allergologicum (CIA) Update 2023.International archives of allergy and immunology · 2023Review
- Esophageal lichen planus: Current knowledge, challenges and future perspectives.World journal of gastroenterology · 2022Review
- Lymphocytic Esophagitis: Assessing Risk Factors and Clinical Outcomes.Digestive diseases and sciences · 2021Article
- Histologic Findings in Mucosa and Muscularis Propria Biopsied During Peroral Endoscopic Myotomy in Patients With Achalasia.Gastroenterology research · 2021Article
- Eosinophilic esophagitis-established facts and new horizons.Seminars in immunopathology · 2021Review
- Article
- Non gastro-esophageal reflux disease related esophagitis: an overview with a histologic diagnostic approach.Pathologica · 2020Review
- Lymphocytic esophagitis: An Australian (Queensland) case series of a newly recognized mimic of eosinophilic esophagitis.JGH open : an open access journal of gastroenterology and hepatology · 2019Article
- Lymphocytic Esophagitis: A Rare Disease on the Rise.Cureus · 2018Article
- Eosinophilic Esophagitis without Eosinophils: Do You Want to Mock Me?Inflammatory intestinal diseasesReview
- Swallowed Topical Tacrolimus Induces Clinical and Histological Remission in a Subset of Patients with Severe Lymphocytic Esophagitis.Inflammatory intestinal diseasesArticle
- Lymphocytic Esophagitis: Navigating an Uncharted Territory.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as old age, female gender and smoking history. This entity was reported in inflammatory bowel disease in the pediatric population but not in adults. Other associations include gastroesophageal reflux disease and primary esophageal motility disorders. The most common symptom is dysphagia, with a normal appearing esophagus on endoscopy, though esophageal rings, webs, nodularities, furrows and strictures have been described. Multiple treatment modalities have been used such as proton pump inhibitors and topical steroids. Esophageal dilation seems to be therapeutic when dysphagia is present along with esophageal narrowing secondary to webs, rings or strictures. The natural history of the disease remains unclear and needs to be better delineated. Overall, lymphocytic esophagitis seems to have a chronic and benign course, except for two cases of esophageal perforation in the literature, thought to be secondary to this entity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.