Evidence map›Paper›PMID 28246395›Full record

ArticleScientific reports2017

RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFA

Stephen Bridgett, Margaret Dellett, David A Simpson

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. VEGF-A related SNPs: a cardiovascular context.Frontiers in cardiovascular medicine · 2023
    Review
  5. Article
  6. Article
  7. VEGFR1 signaling in retinal angiogenesis and microinflammation.Progress in retinal and eye research · 2021
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2.International journal of molecular sciences · 2018
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Stephen BridgettCentre for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK.ORCID 0000-0001-9330-5820
Margaret DellettCentre for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK.
David A SimpsonCentre for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK. David.Simpson@qub.ac.uk.ORCID 0000-0003-0157-1211
Queen's University Belfast · GB

Funding

Medical Research Council MR/K001744/1
6 · The paper itself

Abstract

Vascular endothelial growth factor (VEGFA), a pivotal regulator of angiogenesis and valuable therapeutic target, is characterised by alternative splicing which generates three principal isoforms, VEGFA

Indexed as

Alternative SplicingHEK293 CellsHumansProtein IsoformsReverse Transcriptase Polymerase Chain ReactionSequence Analysis, RNAVascular Endothelial Growth Factor AProtein IsoformsVascular Endothelial Growth Factor A

Identifiers

PMID28246395
PMCPMC5427905
OpenAlexW2592862851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.