Evidence map›Paper›PMID 28246353›Full record

ArticleBioscience reports2017

Long non-coding RNA MIAT acts as a biomarker in diabetic retinopathy by absorbing

Jiayu Zhang, Maochong Chen, Jiawei Chen, Sisi Lin, Daqiu Cai, Chengwei Chen, Zhenguo Chen

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 89 citations in OpenAlex.

  1. Role of Chromatin-Associated RNAs in Eye Physiology and Pathology.Methods in molecular biology (Clifton, N.J.) · 2027
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  5. Article
  6. Article
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  9. Non-coding RNA research · 2024
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  11. Role of LncRNA MIAT in Diabetic Complications.Current medicinal chemistry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiayu ZhangDepartment of Ophthalmology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang Ruian 325200, China.
Maochong ChenDepartment of Ophthalmology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang Ruian 325200, China.
Jiawei ChenDepartment of Ophthalmology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang Ruian 325200, China.
Sisi LinDepartment of Ophthalmology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang Ruian 325200, China.
Daqiu CaiDepartment of Ophthalmology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang Ruian 325200, China.
Chengwei ChenDepartment of Ophthalmology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang Ruian 325200, China.
Zhenguo ChenDepartment of Ophthalmology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang Ruian 325200, China chenzhenguo016@163.com.
Wenzhou Medical University · CNRuian People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a complication of diabetes mellitus (DM) and is the leading cause of vision loss globally. However, the pathogenic mechanism and clinical therapy still needs further improvement. The biologic significance of myocardial infarction associated transcript (MIAT) in DR remains unknown. Here, we aim to explore the mechanism between MIAT and DR, which is essential for RD. Streptozotocin (STZ) was used to induce DM mice and high glucose was used to stimulate cells. ChIP was used to detect the binding activity between nuclear factor κB (NF-κB) and the promoter of the MIAT gene, luciferase activity assay was used to detect the target-specific selectivity between

Indexed as

ApoptosisGene Expression RegulationAnimalsCell LineDiabetes Mellitus, ExperimentalDiabetic RetinopathyGenetic MarkersMaleMiceMicroRNAsRatsRNA, Long NoncodingUp-RegulationGenetic MarkersMiat long non-coding RNAMicroRNAsMIRN29 microRNA, mouseRNA, Long Noncodingcell apoptosisdiabetic retinopathyhigh glucoseMIATmiR-29b

Identifiers

PMID28246353
PMCPMC5408653
OpenAlexW2594076864

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.