Evidence map›Paper›PMID 28246293›Full record

ArticleDiabetes2017

A Whole-Genome RNA Interference Screen Reveals a Role for

Zachary Pappalardo, Deeksha Gambhir Chopra, Thomas G Hennings, Hunter Richards, Justin Choe, Katherine Yang, Luc Baeyens, Kenny Ang, Steven Chen, Michelle Arkin and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Zachary PappalardoDiabetes Center, University of California, San Francisco, San Francisco, CA.
Deeksha Gambhir ChopraDiabetes Center, University of California, San Francisco, San Francisco, CA.
Thomas G HenningsDiabetes Center, University of California, San Francisco, San Francisco, CA.
Hunter RichardsDiabetes Center, University of California, San Francisco, San Francisco, CA.
Justin ChoeDiabetes Center, University of California, San Francisco, San Francisco, CA.
Katherine YangDiabetes Center, University of California, San Francisco, San Francisco, CA.
Luc BaeyensDiabetes Center, University of California, San Francisco, San Francisco, CA.
Kenny AngSmall Molecule Discovery Center, University of California, San Francisco, San Francisco, CA.
Steven ChenSmall Molecule Discovery Center, University of California, San Francisco, San Francisco, CA.
Michelle ArkinSmall Molecule Discovery Center, University of California, San Francisco, San Francisco, CA.
Michael S GermanDiabetes Center, University of California, San Francisco, San Francisco, CA.
Michael T McManusDiabetes Center, University of California, San Francisco, San Francisco, CA.
Gregory M KuDiabetes Center, University of California, San Francisco, San Francisco, CA gregory.ku@ucsf.edu.
University of California, San Francisco · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
DIABETES, ENDOCRINOLOGY &METABOLISM TRAINING PROGRAMT32DK007418 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 1986 to 2026
$14.3M
DIFFERENTIATION IN THE ENDOCRINE AND EXOCRINE PANCREASR01DK021344 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 1986 to 2014
$3.4M
The role of Spry2 in beta cell function and the unfolded protein responseR01DK107650 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KU, GREGORY MICHAEL · 2016 to 2020
$1.8M
Whole genome RNA-interference screen for novel regulators of the insulin promoterRC1DK086290 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCMANUS, MICHAEL T · 2009 to 2010
$995k
Unlocking the Hidden KinomeU01MH105028 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCMANUS, MICHAEL T · 2014 to 2016
$978k
Discovering and dissecting new regulators of insulin production in beta cellsK08DK087945 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KU, GREGORY MICHAEL · 2011 to 2015
$747k
NIDDK NIH HHS K08 DK087945NIDDK NIH HHS P30 DK063720NIDDK NIH HHS R01 DK021344NIDDK NIH HHS R01 DK107650NIDDK NIH HHS RC1 DK086290NIDDK NIH HHS T32 DK007418NIMH NIH HHS U01 MH105028
6 · The paper itself

Abstract

Insulin production by the pancreatic β-cell is required for normal glucose homeostasis. While key transcription factors that bind to the insulin promoter are known, relatively little is known about the upstream regulators of insulin transcription. Using a whole-genome RNA interference screen, we uncovered 26 novel regulators of insulin transcription that regulate diverse processes including oxidative phosphorylation, vesicle traffic, and the unfolded protein response (UPR). We focused on

Indexed as

AnimalsAnnexin A5Blotting, WesternCalciumCell LineDiabetes Mellitus, Type 2eIF-2 KinaseEndoplasmic ReticulumGene Expression RegulationGene Knockdown TechniquesGenome-Wide Association StudyHumansHyperglycemiaInsulinInsulin-Secreting CellsIntracellular Signaling Peptides and ProteinsAnnexin A5CalciumeIF-2 KinaseInsulinIntracellular Signaling Peptides and ProteinsMembrane ProteinsProtein Serine-Threonine KinasesSarcoplasmic Reticulum Calcium-Transporting ATPasesSPRY2 protein, humanSpry2 protein, mouse

Identifiers

PMID28246293
PMCPMC5440024
OpenAlexW2593739107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.