Trial reportHeart (British Cardiac Society)2017
Symptoms and quality of life in patients with suspected angina undergoing CT coronary angiography: a randomised controlled trial.
Trial report in Heart (British Cardiac Society), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Multidetector Computed Tomography in the Diagnosis and Management of Patients Attending a Rapid Access Chest Pain Clinic
CORonary MICrovascular Angina (CorMicA): a Randomised, Controlled, Pilot Trial
Angina in Patients Without Obstructive Coronary Disease as Revealed by CT Coronary Angiography (Cor-CTCA): an Observational Cohort Study Involving Coronary Function Tests and a Nested Randomised Trial
The Clinical Utility Of Cardiac Magnetic Resonance Imaging in Patients With Angina But No Obstructive Coronary Disease (CorCMR): A Diagnostic Study And Nested Randomised Trial
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- SCCT 2021 Expert Consensus Document on Coronary Computed Tomographic Angiography: A Report of the Society of Cardiovascular Computed Tomography.Journal of cardiovascular computed tomographyGuideline
- Endotyping-informed therapy for patients with chest pain and no obstructive coronary artery disease: a randomized trial.Nature medicine · 2026Trial
- Randomised trial of stable chest pain investigation: 3-year clinical and quality of life results from CE-MARC 2.Open heart · 2023Trial
- Cost-effectiveness of cardiovascular imaging for stable coronary heart disease.Heart (British Cardiac Society) · 2021Trial
- Validation of European Society of Cardiology pre-test probabilities for obstructive coronary artery disease in suspected stable angina.European heart journal. Quality of care & clinical outcomes · 2020Trial
- Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain.Health and quality of life outcomes · 2020Trial
- Sex associations and computed tomography coronary angiography-guided management in patients with stable chest pain.European heart journal · 2020Trial
- 1-Year Outcomes of Angina Management Guided by Invasive Coronary Function Testing (CorMicA).JACC. Cardiovascular interventions · 2020 · on this mapTrial
- Dietary glycemic and insulin indices in association with sleep quality and duration in patients undergoing angiography.BMC nutrition · 2025Article
- Great Debate: Computed tomography coronary angiography should be the initial diagnostic test in suspected angina.European heart journal · 2023Article
- Establishment and validation of an AI-aid method in the diagnosis of myocardial perfusion imaging.BMC medical imaging · 2023Article
- Reappraising Ischemic Heart Disease in Women.Reviews in cardiovascular medicine · 2023Review
- Article
- What Is the Role of Assessing Ischemia to Optimize Therapy and Outcomes for Patients with Stable Angina and Non-obstructed Coronary Arteries?Cardiovascular drugs and therapy · 2022Review
- Clinical applications of cardiac computed tomography: a consensus paper of the European Association of Cardiovascular Imaging-part I.European heart journal. Cardiovascular Imaging · 2022Article
- Stable ischemic heart disease: re-appraisal of coronary revascularization criteria in the light of contemporary evidence.Cardiovascular diagnosis and therapy · 2020Review
- SCOT-HEART trial: reshuffling our approach to stable ischemic heart disease.The British journal of radiology · 2020Article
- Coronary microvascular disease: the next frontier for Cardiovascular Research.Cardiovascular research · 2020Article
- Angina: contemporary diagnosis and management.Heart (British Cardiac Society) · 2020Review
- Rationale and design of the British Heart Foundation (BHF) Coronary Microvascular Function and CT Coronary Angiogram (CorCTCA) study.American heart journal · 2020Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundIn patients with suspected angina pectoris, CT coronary angiography (CTCA) clarifies the diagnosis, directs appropriate investigations and therapies, and reduces clinical events. The effect on patient symptoms is currently unknown.
methodsIn a prospective open-label parallel group multicentre randomised controlled trial, 4146 patients with suspected angina due to coronary heart disease were randomised 1:1 to receive standard care or standard care plus CTCA. Symptoms and quality of life were assessed over 6 months using the Seattle Angina Questionnaire and Short Form 12.
resultsBaseline scores indicated mild physical limitation (74±0.4), moderate angina stability (44±0.4), modest angina frequency (68±0.4), excellent treatment satisfaction (92±0.2) and moderate impairment of quality of life (55±0.3). Compared with standard care alone, CTCA was associated with less marked improvements in physical limitation (difference -1.74 (95% CIs, -3.34 to -0.14), p=0.0329), angina frequency (difference -1.55 (-2.85 to -0.25), p=0.0198) and quality of life (difference -3.48 (-4.95 to -2.01), p<0.0001) at 6 months. For patients undergoing CTCA, improvements in symptoms were greatest in those diagnosed with normal coronary arteries or who had their preventative therapy discontinued, and least in those with moderate non-obstructive disease or had a new prescription of preventative therapy (p<0.001 for all).
conclusionsWhile improving diagnosis, treatment and outcome, CTCA is associated with a small attenuation of the improvements in symptoms and quality of life due to the detection of moderate non-obstructive coronary artery disease. TRIAL REGISTRATION NUMBER: NCT01149590.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.