Evidence map›Paper›PMID 28246171›Full record

ArticleThe Journal of biological chemistry2017

A distal ligand mutes the interaction of hydrogen sulfide with human neuroglobin.

Markus Ruetz, Jacques Kumutima, Brianne E Lewis, Milos R Filipovic, Nicolai Lehnert, Timothy L Stemmler, Ruma Banerjee

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 59 citations in OpenAlex.

  1. The first and second zinc finger domains from Poly-ADP-ribose polymerase 1 (PARP1) are modified by hydrogen sulfide.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  2. Review
  3. Power and poison: The intersections of HThe Journal of biological chemistry · 2025
    Review
  4. Review
  5. HProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Hydrogen Sulfide (HBiomolecules · 2024
    Review
  7. Review
  8. Emerging Chemical Biology of Protein Persulfidation.Antioxidants & redox signaling · 2023
    Review
  9. Review
  10. A Metabolic Paradigm for Hydrogen Sulfide SignalingAntioxidants & redox signaling · 2023
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Regulation of the redox metabolome and thiol proteome by hydrogen sulfide.Critical reviews in biochemistry and molecular biology · 2021
    Article
  16. Review
  17. HThe Journal of biological chemistry · 2020
    Review
  18. Review
  19. Hydrogen sulfide signaling in mitochondria and disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Markus RuetzFrom the Department of Biological Chemistry and.
Jacques Kumutimathe Departments of Chemistry and Biophysics, University of Michigan, Ann Arbor, Michigan 48109.
Brianne E Lewisthe Department of Pharmaceutical Science, Wayne State University, Detroit, Michigan 48201-2417.
Milos R Filipovicthe University of Bordeaux, IBGC, UMR 5090, F33077 Bordeaux, France, and.
Nicolai Lehnertthe Departments of Chemistry and Biophysics, University of Michigan, Ann Arbor, Michigan 48109.
Timothy L Stemmlerthe Department of Pharmaceutical Science, Wayne State University, Detroit, Michigan 48201-2417.
Ruma BanerjeeFrom the Department of Biological Chemistry and rbanerje@umich.edu.
University of Michigan–Ann Arbor · USWayne State University · USCentre National de la Recherche Scientifique · FR

Funding

Structural Insights into the Function of FrataxinR01DK068139 · NIDDK · WAYNE STATE UNIVERSITY · PI STEMMLER, TIMOTHY LOUIS · 2005 to 2015
$3.5M
Detroit Cardiovascular Training ProgramT32HL120822 · NHLBI · WAYNE STATE UNIVERSITY · PI LEVY, PHILLIP DAVID · 2014 to 2023
$1.8M
Enzymology of Sulfide OxidationR01GM112455 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BANERJEE, RUMA V · 2014 to 2017
$1.2M
NHLBI NIH HHS T32 HL120822NIDDK NIH HHS R01 DK068139NIGMS NIH HHS R01 GM112455
6 · The paper itself

Abstract

Hydrogen sulfide is a critical signaling molecule, but high concentrations cause cellular toxicity. A four-enzyme pathway in the mitochondrion detoxifies H

Indexed as

CatalysisCrystallography, X-RayCysteineElectron Spin Resonance SpectroscopyGlobinsHemeHemoglobinsHistidineHumansHydrogen-Ion ConcentrationHydrogen SulfideKineticsLigandsMass SpectrometryMutationMyoglobinCysteineGlobinsHemeHemoglobinsHistidineHydrogen SulfideLigandsMyoglobinNerve Tissue ProteinsNeuroglobinOxygenSulfidesThiosulfatesThrombinglobinhemehydrogen sulfideneuroglobinRaman spectroscopyspectroscopyX-ray absorption spectroscopy

Identifiers

PMID28246171
PMCPMC5399104
OpenAlexW2594701760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.