Evidence map›Paper›PMID 28246142›Full record

Observational studyBMJ open2017

Evaluating the effectiveness, impact and safety of live attenuated and seasonal inactivated influenza vaccination: protocol for the Seasonal Influenza Vaccination Effectiveness II (SIVE II) study.

Colin R Simpson, Nazir I Lone, Kimberley Kavanagh, Chris Robertson, Jim McMenamin, Beatrix von Wissmann, Eleftheria Vasileiou, Chris Butler, Lewis D Ritchie, Rory Gunson and 2 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Effectiveness of Influenza Vaccines in Asthma: A Systematic Review and Meta-Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Uptake and effectiveness of influenza vaccine in those aged 65 years and older in the United Kingdom, influenza seasons 2010/11 to 2016/17.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Colin R SimpsonAsthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-5194-8083
Nazir I LoneAsthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.
Kimberley KavanaghDepartment of Mathematics and Statistics, University of Strathclyde, Glasgow, UK.
Chris RobertsonDepartment of Mathematics and Statistics, University of Strathclyde, Glasgow, UK.
Jim McMenaminHealth Protection Scotland, Glasgow, UK.
Beatrix von WissmannHealth Protection Scotland, Glasgow, UK.
Eleftheria VasileiouAsthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.
Chris ButlerNuffield Department of Primary Care Health Sciences, Oxford University, New Radcliffe House, Radcliffe Observatory Quarter, Oxford, UK.
Lewis D RitchieCentre of Academic Primary Care, University of Aberdeen, UK.
Rory GunsonWest of Scotland Specialist Virology Centre, Glasgow, UK.
Jürgen SchwarzeChild Life & Health and MRC-Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK.
Aziz SheikhAsthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.
Asthma UK · GBHealth Protection Scotland · GBUniversity of Strathclyde · GBCentre for Inflammation Research · GBUniversity of Aberdeen · GBUniversity of Oxford · GB

Funding

Chief Scientist Office AUKCAR/14/03Department of Health HTA/13/34/14Medical Research Council G0901697Medical Research Council MC_PC_13040Medical Research Council MR/K007017/1Medical Research Council MR/M501633/1Medical Research Council MR/M501633/2
6 · The paper itself

Abstract

introductionSeasonal (inactivated) influenza vaccination is recommended for all individuals aged 65+ and in individuals under 65 who are at an increased risk of complications of influenza infection, for example, people with asthma METHODS AND ANALYSIS: Test negative and cohort study designs will be used to estimate VE. A primary care database covering 1.25 million people in Scotland for the period 2000/2001 to 2015/2016 will be linked to the Scottish Immunisation Recall Service (SIRS), Health Protection Scotland virology database, admissions to Scottish hospitals and the Scottish death register. Vaccination status (including LAIV uptake) will be determined from the primary care and SIRS database. The primary outcome will be influenza-positive real-time PCR tests carried out in sentinel general practices and other healthcare settings. Secondary outcomes include influenza-like illness and asthma-related general practice consultations, hospitalisations and death. An instrumental variable analysis will be carried out to account for confounding. Self-controlled study designs will be used to estimate the risk of adverse events associated with influenza vaccination. ETHICS AND DISSEMINATION: We obtained approval from the National Research Ethics Service Committee, West Midlands-Edgbaston. The study findings will be presented at international conferences and published in peer-reviewed journals. TRIAL REGISTRATION NUMBER: ISRCTN88072400; Pre-results.

Indexed as

AdolescentAdultAgedAged, 80 and overAsthmaChildChild, PreschoolCohort StudiesDatabases, FactualFemaleHospitalizationHumansInfantInfant, NewbornInfluenza, HumanInfluenza VaccinesInfluenza VaccinesVaccines, AttenuatedEPIDEMIOLOGYINFECTIOUS DISEASES

Identifiers

PMID28246142
PMCPMC5337698
OpenAlexW2592698165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.