ArticleDevelopmental cell2017
Eye Absence Does Not Regulate Planarian Stem Cells during Eye Regeneration.
Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Lack of specificity of planarian progenitor responses to injury in regeneration.bioRxiv : the preprint server for biology · 2026Article
- A Post-Surgical Retinal Progenitor Cell Niche is the Primary Source of Embryonic Eye Regrowth inbioRxiv : the preprint server for biology · 2026Article
- Single-cell transcriptomics and RNAi screening define a hierarchical program of planarian eye regeneration.Cell reports · 2026Article
- Single-nucleotide m⁶A mapping uncovers redundant YTHDF function in planarian progenitor fate selection.The EMBO journal · 2026Article
- Enhanced RNA quality control maintains long-term regenerative ability in planarians.Development (Cambridge, England) · 2025Article
- Article
- Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians.Heliyon · 2025Review
- Reduced adult stem cell fate specification led to eye reduction in cave planarians.Nature communications · 2025Article
- Adaptive robustness through incoherent signaling mechanisms in a regenerative brain.Cell reports · 2024Article
- Fate specification is spatially intermingled across planarian stem cells.Nature communications · 2023Article
- Review
- m6A is required for resolving progenitor identity during planarian stem cell differentiation.The EMBO journal · 2022Article
- Positional Information and Stem Cells Combine to Result in Planarian Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
- An Emerging Frontier in Intercellular Communication: Extracellular Vesicles in Regeneration.Frontiers in cell and developmental biology · 2022Review
- Principles of regeneration revealed by the planarian eye.Current opinion in cell biology · 2021Review
- Transcription Factors Active in the Anterior Blastema ofBiomolecules · 2021Article
- Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression.Biomolecules · 2021Review
- Planarian stem cells specify fate yet retain potency during the cell cycle.Cell stem cell · 2021Article
- Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration.eLife · 2021Article
- Regeneration of Planarian Auricles and Reestablishment of Chemotactic Ability.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Dividing cells called neoblasts contain pluripotent stem cells and drive planarian flatworm regeneration from diverse injuries. A long-standing question is whether neoblasts directly sense and respond to the identity of missing tissues during regeneration. We used the eye to investigate this question. Surprisingly, eye removal was neither sufficient nor necessary for neoblasts to increase eye progenitor production. Neoblasts normally increase eye progenitor production following decapitation, facilitating regeneration. Eye removal alone, however, did not induce this response. Eye regeneration following eye-specific resection resulted from homeostatic rates of eye progenitor production and less cell death in the regenerating eye. Conversely, large head injuries that left eyes intact increased eye progenitor production. Large injuries also non-specifically increased progenitor production for multiple uninjured tissues. We propose a model for eye regeneration in which eye tissue production by planarian stem cells is not directly regulated by the absence of the eye itself.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.