ArticlePloS one2017
Hypoglycemia following intravenous insulin plus glucose for hyperkalemia in patients with impaired renal function.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Management of hyperkalemia: strategic clinical actions in real-world practice.Clinical and experimental nephrology · 2025Review
- Hyperkalemia Management with Intravenous Insulin in Patients with Reduced Kidney Function.Journal of clinical medicine · 2024Article
- Predicting hypoglycemia after treatment of hyperkalemia with insulin and glucose (Glu-K60 score).BMC emergency medicine · 2022Article
- Frequency of serum blood glucose monitoring after hyperkalaemia treatment using insulin and dextrose.Journal of Taibah University Medical Sciences · 2022Article
- Hypoglycaemia due to insulin therapy for the management of hyperkalaemia in hospitalised adults: A scoping review.PloS one · 2022Article
- [Cardiac arrest under special circumstances].Notfall & rettungsmedizin · 2021Review
- The Association of Insulin-dextrose Treatment with Hypoglycemia in Patients with Hyperkalemia.Scientific reports · 2020Article
- Comparison of IV Insulin Dosing Strategies for Hyperkalemia in the Emergency Department.Critical care explorations · 2020Article
- Hypoglycemia Associated With Insulin Use During Treatment of Hyperkalemia Among Emergency Department Patients.Hospital pharmacy · 2019Article
- Management of hyperkalemia in the acutely ill patient.Annals of intensive care · 2019Review
- Treatment of Hyperkalemia With a Low-Dose Insulin Protocol Is Effective and Results in Reduced Hypoglycemia.Kidney international reports · 2018Article
- A Systematic Approach for the Prevention and Reduction of Hypoglycemia in Hospitalized Patients.Current diabetes reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypoglycemia is a serious complication following the administration of insulin for hyperkalemia. We determined the incidence of hypoglycemia and severe hypoglycemia (blood glucose <70 or ≤40 mg/dl, respectively) in a cohort of AKI and non-dialysis dependent CKD patients who received an intravenous infusion of insulin plus glucose to treat hyperkalemia.
methodsWe retrospectively reviewed charts of all AKI and non-dialysis dependent CKD patients who received 10 U of insulin plus 50 g glucose to treat hyperkalemia from December 1, 2013 to May 31, 2015 at our Department.
resultsOne hundred sixty four episodes of hyperkalemia were treated with insulin plus glucose and were eligible for analysis. Serum potassium levels dropped by 1.18 ± 1.01 mmol/l. Eleven treatments (6.1%) resulted in hypoglycemia and two (1.2%) in severe hypoglycemia. A lower pretreatment blood glucose tended to associate with a higher subsequent risk of hypoglycemia. Age, sex, renal function, an established diagnosis of diabetes or previous treatment were not associated with the development of this complication. We did not register any significant adverse events.
conclusionOur intravenous regimen combining an infusion of insulin plus glucose effectively reduced serum potassium levels compared to previous studies and associated a low risk of symptomatic hypoglycemia and other complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.