ArticleThe Journal of cell biology1987
Morphology of astroglial cells is controlled by beta-adrenergic receptors.
Article in The Journal of cell biology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 113 citations in OpenAlex.
- Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain.International journal of oral science · 2025Article
- β-Adrenergic Signaling Promotes Morphological Maturation of Astrocytes in Female Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The neurophysiological basis of excessive daytime sleepiness: suggestions of an altered state of consciousness.Sleep & breathing = Schlaf & Atmung · 2020Review
- Activity changes in neuron-astrocyte networks in culture under the effect of norepinephrine.PloS one · 2018Article
- Astroglial Vesicular Trafficking in Neurodegenerative Diseases.Neurochemical research · 2017Article
- Astrocytic Pathological Calcium Homeostasis and Impaired Vesicle Trafficking in Neurodegeneration.International journal of molecular sciences · 2017Review
- Thyroid Hormone-Induced Differentiation of Astrocytes is Associated with Transcriptional Upregulation of β-arrestin-1 and β-adrenergic Receptor-Mediated Endosomal Signaling.Molecular neurobiology · 2016Article
- The homeostatic astroglia emerges from evolutionary specialization of neural cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Activation of β-adrenergic receptors in rat visual cortex expands astrocytic processes and reduces extracellular space volume.Synapse (New York, N.Y.) · 2016Article
- Adrenergic activation attenuates astrocyte swelling induced by hypotonicity and neurotrauma.Glia · 2016Article
- Memory Formation Shaped by Astroglia.Frontiers in integrative neuroscience · 2015Review
- Article
- Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice.British journal of pharmacology · 2011Article
- Increased beta(2)-adrenergic receptor activity by thyroid hormone possibly leads to differentiation and maturation of astrocytes in culture.Cellular and molecular neurobiology · 2007Article
- Adrenergic activation of steroid 5alpha-reductase gene expression in rat C6 glioma cells: involvement of cyclic amp/protein kinase A-mediated signaling pathway.Journal of molecular neuroscience : MN · 2004Article
- Thyroid hormone actions on neural cells.Cellular and molecular neurobiology · 2002Review
- Astroglial differentiation of cortical precursor cells triggered by activation of the cAMP-dependent signaling pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Basolateral amygdala noradrenergic influences on memory storage are mediated by an interaction between beta- and alpha1-adrenoceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- beta 2-adrenoreceptor immunoreactivity in cardiac ganglia of the guinea pig.The Histochemical journal · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Astroglial cells in vivo and in vitro respond to hormones, growth factors, and neurotransmitters by changing from an epithelial-like to stellate morphology. We have studied the temporal relationship between receptor activation, second messenger mobilization, and morphological changes using LRM55 astroglial cells. Maintenance of an altered morphology required continuous beta-adrenergic receptor activation. These changes appeared to be mediated by cAMP since they were elicited by its analogue, dibutyryl cAMP, and by forskolin, a direct activator of adenylate cyclase. Changes in cell morphology may require a relatively small increase in intracellular cAMP, since receptor-stimulated changes in cAMP levels were transient and peaked approximately 5 min after receptor activation while changes in morphology took at least 30 min to reach a new steady state. Time-lapse videomicroscopy and high voltage electron microscopy indicated that receptor activation resulted in a sequence of morphological events. Time-lapse observations revealed the development and enlargement of openings through the cytoplasm associated with cytoplasmic withdrawal to the perinuclear region and process formation. Higher resolution high voltage electron microscopy indicated that the transition to a stellate morphology was preceded by the appearance of two distinct cytoplasmic domains. One contained an open network of filaments and organelles. The other was characterized by short broad cytoplasmic filaments. The first domain was similar to cytoplasm in control cells while the second was associated with the development and enlargement of openings through the cytoplasm and regions of obvious cytoplasmic withdrawal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.