ArticlePloS one2017
The effect of size-segregated ambient particulate matter on Th1/Th2-like immune responses in mice.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Particulates induced lung inflammation and its consequences in the development of restrictive and obstructive lung diseases: a systematic review.Environmental science and pollution research international · 2021Pooled it
- Associations between the infant gut microbiota and the living environment.Gut microbes reports · 2026Article
- Maternal Cigarette Smoke Exposure Does Not Impair Influenza Vaccine Responsiveness in Murine Offspring.Vaccines · 2025Article
- Benzo[b]fluoranthene is involved in idiopathic membranous nephropathy by inducing podocyte injury.Journal of translational internal medicine · 2025Article
- Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases.Journal of translational autoimmunity · 2024Review
- Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model.Journal of inflammation (London, England) · 2024Article
- Long-term associations of PMERJ open research · 2024Article
- Causal association between air pollution and allergic rhinitis, asthma: a Mendelian randomization study.Frontiers in public health · 2024Article
- Adjuvant effect of inhaled particulate matter containing free radicals following house-dust mite induction of asthma in mice.Inhalation toxicology · 2023Article
- Environmental and occupational bronchiolitis obliterans: new reality.EBioMedicine · 2023Review
- Pulmonary microbiota intervention alleviates fine particulate matter-induced lung inflammation in broilers.Journal of animal science · 2023Article
- The relationship between PM2.5 and the onset and exacerbation of childhood asthma: a short communication.Frontiers in pediatrics · 2023Article
- RNA-Seq Analysis of UPM-Exposed Epithelium Co-Cultivated with Macrophages and Dendritic Cells in Obstructive Lung Diseases.International journal of molecular sciences · 2022Article
- Cytotoxicity of Particulate Matter PMJournal of toxicology · 2022Article
- Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980-2020.Heliyon · 2022Review
- Air Pollution Relates to Airway Pathology in Children with Wheezing.Annals of the American Thoracic Society · 2021Article
- Systems level insights into the impact of airborne exposure on SARS-CoV-2 pathogenesis and COVID-19 outcome - A multi-omics big data study.Gene reports · 2021Article
- Effects of Fine Particulate Matter and Its Components on Emergency Room Visits for Pediatric Pneumonia: A Time-Stratified Case-Crossover Study.International journal of environmental research and public health · 2021Article
- Fine particulate matter constituents associated with emergency room visits for pediatric asthma: a time-stratified case-crossover study in an urban area.BMC public health · 2021Article
- Establishment of particulate matter-induced lung injury model in mouse.Laboratory animal research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParticulate matter (PM) has been associated with increased pulmonary and cardiovascular mortality and morbidity. Additionally, PM is known to exacerbate asthma. However, whether ambient PM exposure contributes to the onset of asthma, especially in non-atopic children and adults, is less conclusive. The current study aimed to evaluate the effects of size-fractioned PM on lung immune responses in healthy BALB/c mice. METHODS AND PRINCIPAL
findingsWe collected PM10, PM2.5, PM1 and PM0.1 samples from October 2012 to August 2013 in the Taipei Basin. These PM samples were representative of urban traffic pollution. The samples were extracted and sonicated in phosphate-buffered saline (PBS). Female BALB/c mice were exposed to the samples via intratracheal instillation at three different doses: 1.75 mg/kg (35 μg/per mouse), 5 mg/kg (100 μg/per mouse), and 12.5 mg/kg (250 μg/per mouse). The mice were exposed on days 0 and 7, and PBS alone was used as a control. Following the exposures, the expression profiles of inflammatory cells and cytokines in bronchoalveolar lavage fluid (BALF) were assessed. Exposure to PM10 resulted in inflammatory responses, including the recruitment of neutrophils and the induction of T helper 1 (Th1) cell-related cytokine release, such as TNF-α and IFN-γ. Furthermore, an allergic immune response, including the recruitment of eosinophils and the up-regulation of T helper 2 (Th2) cell-related cytokine release, such as IL-5 and IL-13, was also observed in the BALF of mice exposed to PM10.
conclusionsOur study showed that exposure to PM alone caused mixed Th1/Th2 inflammatory responses in healthy mice. These findings support the hypothesis that PM may contribute to the onset of asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.