Evidence map›Paper›PMID 28245176›Full record

ArticleJournal of psychiatry & neuroscience : JPN2017

Familial and environmental influences on brain volumes in twins with schizophrenia.

Marco M Picchioni, Fruhling Rijsdijk, Timothea Toulopoulou, Christopher Chaddock, James H Cole, Ulrich Ettinger, Ana Oses, Hugo Metcalfe, Robin M Murray, Philip McGuire

Abstract readMulticenter StudyTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. NMDA receptor modulation by Esculetin: Investigating behavioral, biochemical and neurochemical effects in schizophrenic mice model.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  5. Article
  6. Review
  7. The social brain in female autism: a structural imaging study of twins.Social cognitive and affective neuroscience · 2020
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marco M PicchioniFrom the St. Andrew's Academic Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni); the Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Toulopoulou, Chaddock, Murray, McGuire); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Metcalfe); the Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Rijsdijk); the Department of Psychology, The University of Hong Kong, Hong Kong (Toulopoulou); the Computational, Cognitive & Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, UK (Cole); the Department of Psychology, University of Bonn, Bonn, Germany (Ettinger); and the Centro de Salut Mental del Ripolles, Institut d'Assistencia Sanitaria de Girona, Girona, Spain (Oses).
Fruhling RijsdijkFrom the St. Andrew's Academic Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni); the Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Toulopoulou, Chaddock, Murray, McGuire); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Metcalfe); the Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Rijsdijk); the Department of Psychology, The University of Hong Kong, Hong Kong (Toulopoulou); the Computational, Cognitive & Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, UK (Cole); the Department of Psychology, University of Bonn, Bonn, Germany (Ettinger); and the Centro de Salut Mental del Ripolles, Institut d'Assistencia Sanitaria de Girona, Girona, Spain (Oses).
Timothea ToulopoulouFrom the St. Andrew's Academic Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni); the Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Toulopoulou, Chaddock, Murray, McGuire); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Metcalfe); the Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Rijsdijk); the Department of Psychology, The University of Hong Kong, Hong Kong (Toulopoulou); the Computational, Cognitive & Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, UK (Cole); the Department of Psychology, University of Bonn, Bonn, Germany (Ettinger); and the Centro de Salut Mental del Ripolles, Institut d'Assistencia Sanitaria de Girona, Girona, Spain (Oses).
Christopher ChaddockFrom the St. Andrew's Academic Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni); the Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Toulopoulou, Chaddock, Murray, McGuire); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Metcalfe); the Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Rijsdijk); the Department of Psychology, The University of Hong Kong, Hong Kong (Toulopoulou); the Computational, Cognitive & Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, UK (Cole); the Department of Psychology, University of Bonn, Bonn, Germany (Ettinger); and the Centro de Salut Mental del Ripolles, Institut d'Assistencia Sanitaria de Girona, Girona, Spain (Oses).
James H ColeFrom the St. Andrew's Academic Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni); the Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Toulopoulou, Chaddock, Murray, McGuire); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Metcalfe); the Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Rijsdijk); the Department of Psychology, The University of Hong Kong, Hong Kong (Toulopoulou); the Computational, Cognitive & Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, UK (Cole); the Department of Psychology, University of Bonn, Bonn, Germany (Ettinger); and the Centro de Salut Mental del Ripolles, Institut d'Assistencia Sanitaria de Girona, Girona, Spain (Oses).
Ulrich EttingerFrom the St. Andrew's Academic Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni); the Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Toulopoulou, Chaddock, Murray, McGuire); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Metcalfe); the Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Rijsdijk); the Department of Psychology, The University of Hong Kong, Hong Kong (Toulopoulou); the Computational, Cognitive & Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, UK (Cole); the Department of Psychology, University of Bonn, Bonn, Germany (Ettinger); and the Centro de Salut Mental del Ripolles, Institut d'Assistencia Sanitaria de Girona, Girona, Spain (Oses).
Ana OsesFrom the St. Andrew's Academic Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni); the Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Toulopoulou, Chaddock, Murray, McGuire); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Metcalfe); the Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Rijsdijk); the Department of Psychology, The University of Hong Kong, Hong Kong (Toulopoulou); the Computational, Cognitive & Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, UK (Cole); the Department of Psychology, University of Bonn, Bonn, Germany (Ettinger); and the Centro de Salut Mental del Ripolles, Institut d'Assistencia Sanitaria de Girona, Girona, Spain (Oses).
Hugo MetcalfeFrom the St. Andrew's Academic Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni); the Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Toulopoulou, Chaddock, Murray, McGuire); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Metcalfe); the Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Rijsdijk); the Department of Psychology, The University of Hong Kong, Hong Kong (Toulopoulou); the Computational, Cognitive & Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, UK (Cole); the Department of Psychology, University of Bonn, Bonn, Germany (Ettinger); and the Centro de Salut Mental del Ripolles, Institut d'Assistencia Sanitaria de Girona, Girona, Spain (Oses).
Robin M MurrayFrom the St. Andrew's Academic Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni); the Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Toulopoulou, Chaddock, Murray, McGuire); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Metcalfe); the Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Rijsdijk); the Department of Psychology, The University of Hong Kong, Hong Kong (Toulopoulou); the Computational, Cognitive & Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, UK (Cole); the Department of Psychology, University of Bonn, Bonn, Germany (Ettinger); and the Centro de Salut Mental del Ripolles, Institut d'Assistencia Sanitaria de Girona, Girona, Spain (Oses).
Philip McGuireFrom the St. Andrew's Academic Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni); the Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Toulopoulou, Chaddock, Murray, McGuire); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Picchioni, Metcalfe); the Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK (Rijsdijk); the Department of Psychology, The University of Hong Kong, Hong Kong (Toulopoulou); the Computational, Cognitive & Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, UK (Cole); the Department of Psychology, University of Bonn, Bonn, Germany (Ettinger); and the Centro de Salut Mental del Ripolles, Institut d'Assistencia Sanitaria de Girona, Girona, Spain (Oses).

Funding

Department of Health RP-PG-0606-1049Medical Research Council G0600972Medical Research Council G0700995Medical Research Council G1100583Medical Research Council MR/K004867/1Medical Research Council MR/K013807/1Medical Research Council MR/N026063/1Wellcome Trust 064971
6 · The paper itself

Abstract

backgroundReductions in whole brain and grey matter volumes are robust features of schizophrenia, yet their etiological influences are unclear.

methodsWe investigated the association between the genetic and environmental risk for schizophrenia and brain volumes. Whole brain, grey matter and white matter volumes were established from structural MRIs from twins varying in their zygosity and concordance for schizophrenia. Hippocampal volumes were measured manually. We conducted between-group testing and full genetic modelling.

resultsWe included 168 twins in our study. Whole brain, grey matter, white matter and right hippocampal volumes were smaller in twins with schizophrenia. Twin correlations were larger for whole brain, grey matter and white matter volumes in monozygotic than dizygotic twins and were significantly heritable, whereas hippocampal volume was the most environmentally sensitive. There was a significant phenotypic correlation between schizophrenia and reductions in all the brain volumes except for that of the left hippocampus. For whole brain, grey matter and the right hippocampus the etiological links with schizophrenia were principally associated with the shared familial environment. Lower birth weight and perinatal hypoxia were both associated with lower whole brain volume and with lower white matter and grey matter volumes, respectively. LIMITATIONS: Scan data were collected across 2 sites, and some groups were modest in size.

conclusionWhole brain, grey matter and right hippocampal volume reductions are linked to schizophrenia through correlated familial risk (i.e., the shared familial environment). The degree of influence of etiological factors varies between brain structures, leading to the possibility of a neuroanatomically specific etiological imprint.

Indexed as

AdultBrainFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleModels, GeneticOrgan SizePhenotypeSchizophreniaTwins, DizygoticTwins, Monozygotic

Identifiers

PMID28245176
PMCPMC5373701

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