Evidence map›Paper›PMID 28245149›Full record

ArticleAmerican journal of respiratory cell and molecular biology2017

Airborne Particulate Matter Induces Nonallergic Eosinophilic Sinonasal Inflammation in Mice.

Murugappan Ramanathan, Nyall R London, Anuj Tharakan, Nitya Surya, Thomas E Sussan, Xiaoquan Rao, Sandra Y Lin, Elina Toskala, Sanjay Rajagopalan, Shyam Biswal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 118 citations in OpenAlex.

  1. Association between air pollution and allergic upper respiratory diseases: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
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  13. Impact of Ambient Air Pollution on Obstructive Sleep Apnea Surgery: A Longitudinal Study.ORL; journal for oto-rhino-laryngology and its related specialties · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Murugappan Ramanathan1 Johns Hopkins Department of Otolaryngology-Head and Neck Surgery, Baltimore, Maryland.
Nyall R London1 Johns Hopkins Department of Otolaryngology-Head and Neck Surgery, Baltimore, Maryland.
Anuj Tharakan1 Johns Hopkins Department of Otolaryngology-Head and Neck Surgery, Baltimore, Maryland.
Nitya Surya1 Johns Hopkins Department of Otolaryngology-Head and Neck Surgery, Baltimore, Maryland.
Thomas E Sussan2 Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Xiaoquan Rao3 Cardiovascular Research Institute, Case Western Reserve School of Medicine, Cleveland, Ohio, and.
Sandra Y Lin1 Johns Hopkins Department of Otolaryngology-Head and Neck Surgery, Baltimore, Maryland.
Elina Toskala4 Temple University Department of Otolaryngology-Head and Neck Surgery, Philadelphia, Pennsylvania.
Sanjay Rajagopalan3 Cardiovascular Research Institute, Case Western Reserve School of Medicine, Cleveland, Ohio, and.
Shyam Biswal2 Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Johns Hopkins University · USCase Western Reserve University · USTemple University · US

Funding

Investigating Effect of Air pollution and Host Defenses in SARS-CoV2 infectionU01ES026721 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI BISWAL, SHYAM, RAJAGOPALAN, SANJAY · 2016 to 2020
$3.8M
Role of the Indoor Environment on Oxidative Stress Related Sinonasal InflammationK23ES020859 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI RAMANATHAN, MURUGAPPAN · 2011 to 2015
$1.2M
NIEHS NIH HHS K23 ES020859NIEHS NIH HHS U01 ES026721
6 · The paper itself

Abstract

Exposure to airborne particulate matter (PM) has been linked to aggravation of respiratory symptoms, increased risk of cardiovascular disease, and all-cause mortality. Although the health effects of PM on the lower pulmonary airway have been extensively studied, little is known regarding the impact of chronic PM exposure on the upper sinonasal airway. We sought to test the impact of chronic airborne PM exposure on the upper respiratory system in vivo. Mice were subjected, by inhalation, to concentrated fine (2.5 μm) PM 6 h/d, 5 d/wk, for 16 weeks. Mean airborne fine PM concentration was 60.92 μm/m

Indexed as

AnimalsEosinophilsEpithelial CellsFluorescent Antibody TechniqueHypersensitivityInflammationInterleukin-13Interleukin-1betaMaleMice, Inbred C57BLNoseParanasal SinusesParticle SizeParticulate MatterInterleukin-13Interleukin-1betaParticulate Matterair pollutioninflammationparticulate matterpermeabilityrhinitis

Identifiers

PMID28245149
PMCPMC5516278
OpenAlexW2592998794

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.