Evidence map›Paper›PMID 28244956›Full record

ArticleAIDS (London, England)2017

Relationship between ever reporting depressive symptoms and all-cause mortality in a cohort of HIV-infected adults in routine care.

Angela M Bengtson, Brian W Pence, Richard Moore, Matthew J Mimiaga, William Christopher Mathews, Amy Heine, Bradley N Gaynes, Sonia Napravnik, Katerina Christopoulos, Heidi M Crane and 1 more

Abstract read
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In one paragraph

Article in AIDS (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Angela M BengtsonaDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina bDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland cDepartments of Behavioral & Social Sciences and Epidemiology School of Public Health dDepartment of Psychiatry & Human Behavior, Alpert Medical School, Brown University, Providence, Rhode Island eThe Fenway Institute, Fenway Health, Boston, Massachusetts fDepartment of Medicine, School of Medicine, University of California, San Diego, San Diego, California gDivision of Infectious Diseases hDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina iHIV/AIDS Division, San Francisco General Hospital, University of California, San Francisco, San Francisco, California jDepartment of Medicine, School of Medicine, University of Washington, Seattle, Washington kDepartment of Medicine and UAB Center for AIDS Research, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Brian W Pence
Richard Moore
Matthew J Mimiaga
William Christopher Mathews
Amy Heine
Bradley N Gaynes
Sonia Napravnik
Katerina Christopoulos
Heidi M Crane
Michael J Mugavero

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
The Causal Effect of Effective Depression Treatment on HIV Outcomes in CNICSR01MH100970 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PENCE, BRIAN W · 2013 to 2015
$1.3M
NIAID NIH HHS P30 AI050410NIAID NIH HHS R24 AI067039NIMH NIH HHS L30 MH110572NIMH NIH HHS R01 MH100970
6 · The paper itself

Abstract

objectiveThe aim of this study was to assess whether ever reporting depressive symptoms affects mortality in the modern HIV treatment era.

designA cohort study of HIV-infected adults in routine clinical care at seven sites in the USA.

methodsWe examined the effect of ever reporting depressive symptoms on all-cause mortality using data from the Centers for AIDS Research Network of Integrated Clinical Systems cohort. We included individuals with at least one depression measure between 2005 and 2014. Depressive symptoms were measured with the Patient Health Questionnaire (PHQ)-9. We used weighted Kaplan-Meier curves and marginal structural Cox models with inverse probability weights to estimate the effect of ever reporting depressive symptoms (PHQ-9 ≥10) on all-cause mortality.

resultsA total of 10 895 individuals were included. Participants were followed for a median of 3.1 years (35 621 total person-years). There were 491 (4.5%) deaths during the follow-up period (crude incidence rate 13.8/1000 person-years). At baseline, 28% of the population reported depressive symptoms. In the weighted analysis, there was no evidence that ever reporting depressive symptoms increased the hazard of all-cause mortality (hazard ratio 0.82, 95% confidence interval 0.55-1.24).

conclusionIn a large cohort of HIV-infected adults in care in the modern treatment era, we observed no evidence that ever reporting depressive symptoms increased the likelihood of all-cause mortality, controlling for a range of time-varying factors. Antiretroviral therapy that is increasingly robust to moderate adherence and improved access to depression treatment may help to explain changes in the relationship between depressive symptoms and mortality in the modern treatment era.

Indexed as

MortalityAdultCohort StudiesDepressionFemaleHIV InfectionsHumansMaleMiddle AgedSurvival AnalysisUnited States

Identifiers

PMID28244956
PMCPMC5373944

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.