ArticleJournal of cellular and molecular medicine2017
Nandrolone decanoate interferes with testosterone biosynthesis altering blood-testis barrier components.
Article in Journal of cellular and molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Nandrolone decanoate-induced hypogonadism in male rats: Dose- and time-dependent effects on pituitary and testicular hormonal functions.Physiological reports · 2024Article
- Supraphysiological doses of nandrolone decanoate disrupts spermatogenesis but did not interfere on embryo rate.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- BCL2-associated athanogene 6 exon24 contributes to testosterone synthesis and male fertility in mammals.Cell proliferation · 2022Article
- Medial tunica degeneration of the ascending aortic wall is associated with specific microRNA changes in bicuspid aortic valve disease.Molecular medicine reports · 2021Article
- Assessment of testicular steroidogenic enzymes expression in experimental animal model following withdrawal of nandrolone decanoate.Journal of animal science and technology · 2021Article
- Forensic Post-Mortem Investigation in AAS Abusers: Investigative Diagnostic Protocol. A Systematic Review.Diagnostics (Basel, Switzerland) · 2021Review
- Adverse Effects of Anabolic-Androgenic Steroids: A Literature Review.Healthcare (Basel, Switzerland) · 2021Review
- Article
- miRNAs as Novel Biomarkers of Chronic Kidney Injury in Anabolic-Androgenic Steroid Users: An Experimental Study.Frontiers in pharmacology · 2020Article
- Neuropsychiatric and Behavioral Involvement in AAS Abusers. A Literature Review.Medicina (Kaunas, Lithuania) · 2019Review
- Effects of nandrolone decanoate on expression of steroidogenic enzymes in the rat testis.Asian-Australasian journal of animal sciences · 2018Article
- Anabolic androgenic steroids and carcinogenicity focusing on Leydig cell: a literature review.Oncotarget · 2018Review
- Primary Motor Cortex Excitability in Karate Athletes: A Transcranial Magnetic Stimulation Study.Frontiers in physiology · 2017Article
- Improvement of Bone Physiology and Life Quality Due to Association of Risedronate and Anastrozole.Frontiers in pharmacology · 2017Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate whether nandrolone decanoate (ND) use affects testosterone production and testicular morphology in a model of trained and sedentary mice. A group of mice underwent endurance training while another set led a sedentary lifestyle and were freely mobile within cages. All experimental groups were treated with either ND or peanut oil at different doses for 6 weeks. Testosterone serum levels were measured via liquid chromatography-mass spectrometry. Western blot analysis and quantitative real-time PCR were utilized to determine gene and protein expression levels of the primary enzymes implicated in testosterone biosynthesis and gene expression levels of the blood-testis barrier (BTB) components. Immunohistochemistry and immunofluorescence were conducted for testicular morphological evaluation. The study demonstrated that moderate to high doses of ND induced a diminished serum testosterone level and altered the expression level of the key steroidogenic enzymes involved in testosterone biosynthesis. At the morphological level, ND induced degradation of the BTB by targeting the tight junction protein-1 (TJP1). ND stimulation deregulated metalloproteinase-9, metalloproteinase-2 (MMP-2) and the tissue inhibitor of MMP-2. Moreover, ND administration resulted in a mislocalization of mucin-1. In conclusion, ND abuse induces a decline in testosterone production that is unable to regulate the internalization and redistribution of TJP1 and may induce the deregulation of other BTB constituents via the inhibition of MMP-2. ND may well be considered as both a potential inducer of male infertility and a potential risk factor to a low endogenous bioavailable testosterone.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.