ArticleJournal of clinical laboratory analysis2018
Iron deficiency anemia interfering the diagnosis of compound heterozygosity for Hb constant spring and Hb Paksé: The first case report.
Article in Journal of clinical laboratory analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Combined heterozygosity for hemoglobin Paksé, α-thalassemia and for hemoglobin E, β- thalassemia ̵ first appearance in Europe.Annals of hematology · 2025Article
- Iron deficiency anemia interfering the diagnosis of compound heterozygosity for Hb constant spring and Hb Paksé: The first case report.Journal of clinical laboratory analysis · 2018Article
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2 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundDiagnosis of thalassemia or hemoglobinopathy concomitant with iron deficiency anemia (IDA) is challenging.
methodWe report a case of 43-year-old female whose diagnosis of compound heterozygosity for hemoglobin Constant Spring (HbCS) and Hb Paksé became apparent after the treatment of IDA.
resultsPrior to treatment, Hb analysis using isoelectric focusing (IEF) showed HbA 95.6%, HbA
conclusionThis case demonstrated that IDA can significantly reduce HbCS/Hb Paksé levels and probably mask the diagnosis of homozygous HbCS, homozygous Hb Paksé or the compound heterozygosity for both hemoglobinopathies by hemoblogin analysis. The test should be repeated after resolution of IDA, or molecular testing should be performed to confirm the diagnosis.
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