ArticleThe journal of nutrition, health & aging2017
Anti-Aging Effect of Riboflavin Via Endogenous Antioxidant in Fruit fly Drosophila Melanogaster.
Article in The journal of nutrition, health & aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels.Oxidative medicine and cellular longevity · 2019Trial
- Chlorophyll Supplementation Delays Aging inNutrients · 2026Article
- Nutrition and longevity - diet in centenarians.Journal of translational medicine · 2026Review
- Rapid adaptive response of population fitness of Zeugodacus tau during host shifts and implications for integrated pest management strategies.Pest management science · 2025Article
- Studying Cellular Senescence Using the Model Organism Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2025Article
- How to assess antioxidant activity? Advances, limitations, and applications of in vitro, in vivo, and ex vivo approaches.Food production, processing and nutrition · 2025Review
- Promising tools into oxidative stress: A review of non-rodent model organisms.Redox biology · 2024Review
- Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care-clinically relevant 3PM innovation.The EPMA journal · 2024Article
- Role of Vitamin B in Healthy Ageing and Disease.Sub-cellular biochemistry · 2024Review
- Review
- Silicon Nanoparticle-Based Ratiometric Fluorescence Probes for Highly Sensitive and Visual Detection of VBACS omega · 2023Article
- Correlation between Dietary Intake of Vitamins and Oral Health Behaviors: A Cross-Sectional Study.International journal of environmental research and public health · 2023Article
- Review
- Reproductive-dependent effects of B vitamin deficiency on lifespan and physiology.Frontiers in nutrition · 2023Article
- An innovative study on the "on-off-on" detection of sulfur ions based on a TSPP-riboflavin fluorescent probe.RSC advances · 2022Article
- Chronic blue light leads to accelerated aging in Drosophila by impairing energy metabolism and neurotransmitter levels.Frontiers in aging · 2022Article
- Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algorithms.Frontiers in aging · 2022Review
- Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999-2002.Frontiers in nutrition · 2022Article
- Riboflavin Inhibits Histamine-Dependent Itch by Modulating Transient Receptor Potential Vanilloid 1 (TRPV1).Frontiers in molecular neuroscience · 2021Article
- Potential Antiaging Effects of DLBS1649, aJournal of experimental pharmacology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study investigated the effect of riboflavin on aging in Drosophila melanogaster (fruit fly).
designExperimental study.
settingNaval Medical Research Institute.
participantsFruit fly Drosophila melanogaster.
interventionAfter lifelong supplement of riboflavin, the lifespan and the reproduction of fruit flies were observed. Hydrogen peroxide (H2O2) was used to mimic oxidative stress damage to fruit flies and the survival time was recorded. MEASUREMENTS: The activity of copper-zinc-containing superoxide dismutase (SOD1), manganese containing SOD (SOD2) and catalase (CAT) and lipofuscin (LF) content were determined.
resultsRiboflavin significantly prolonged the lifespan (Log rank χ2=16.677, P<0.001) and increased the reproductive capacity (P<0.01 for day 15; P<0.05 for day 30) of fruit flies by lifelong supplement. The survival time of fruit flies damaged by H2O2 was significantly prolonged (Log rank χ2=15.886, P<0.001), the activity of SOD1 (P<0.01) and CAT (P<0.01) was enhanced, and the accumulation of LF (P<0.01) was inhibited by riboflavin supplement.
conclusionRiboflavin prolonged the lifespan and increased the reproduction of fruit flies through anti-oxidative stress pathway involving enhancing the activity of SOD1 and CAT and inhibiting LF accumulation. Riboflavin deserves more attention for slowing human aging.
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Registered trials
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