ArticleLab on a chip2017
A microfluidic perfusion approach for on-chip characterization of the transport properties of human oocytes.
Article in Lab on a chip, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Microfluidic chips in female reproduction: a systematic review of status, advances, and challenges.Theranostics · 2024Pooled it
- Microfluidics for in vitro fertilization: from science to clinical validation.Human reproduction update · 2026Review
- Microfluidic Platforms for Cryopreservation.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Vitrification of bovine oocytes and embryos: roadmaps to cryopreservation success.Animal reproduction · 2026Article
- Principles Underlying Cryopreservation and Freeze-Drying of Cells.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Oocytes Vitrification Using Automated Equipment Based on Microfluidic Chip.Annals of biomedical engineering · 2025Article
- The Effects of Endometrial Mesenchymal Stem Cells on TheInternational journal of fertility & sterility · 2024Article
- Microfluidic chip as a promising evaluation method in assisted reproduction: A systematic review.Bioengineering & translational medicine · 2024Review
- Revolutionizing the female reproductive system research using microfluidic chip platform.Journal of nanobiotechnology · 2023Review
- Recent advances and challenges in temperature monitoring and control in microfluidic devices.Electrophoresis · 2023Review
- Noncovalent reversible binding-enabled facile fabrication of leak-free PDMS microfluidic devices without plasma treatment for convenient cell loading and retrieval.Bioactive materials · 2022Article
- Loading equine oocytes with cryoprotective agents captured with a finite element method model.Scientific reports · 2021Article
- Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy.Bioactive materials · 2021Review
- Toward embryo cryopreservation-on-a-chip: A standalone microfluidic platform for gradual loading of cryoprotectants to minimize cryoinjuries.Biomicrofluidics · 2021Article
- Mathematical Modeling and Optimization of Cryopreservation in Single Cells.Methods in molecular biology (Clifton, N.J.) · 2021Article
- A single-cell identification and capture chip for automatically and rapidly determining hydraulic permeability of cells.Analytical and bioanalytical chemistry · 2020Article
- A microfluidic approach for synchronous and nondestructive study of the permeability of multiple oocytes.Microsystems & nanoengineering · 2020Article
- Human oocytes and zygotes are ready for ultra-fast vitrification after 2 minutes of exposure to standard CPA solutions.Scientific reports · 2019Article
- A Multiwell Microfluidic Device for Analyzing and Screening Nonhormonal Contraceptive Agents.Small (Weinheim an der Bergstrasse, Germany) · 2019Article
- Hydrogel Encapsulation Facilitates Rapid-Cooling Cryopreservation of Stem Cell-Laden Core-Shell Microcapsules as Cell-Biomaterial Constructs.Advanced healthcare materials · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Accurate characterization of the cell membrane transport properties of human oocytes is of great significance to reproductive pharmacology, fertility preservation, and assisted reproduction. However, the commonly used manual method for quantifying the transport properties is associated with uncontrolled operator-to-operator and run-to-run variability. Here, we report a novel sandwich structured microfluidic device that can be readily fabricated for characterizing oocyte membrane transport properties. Owing to its capacity for excellent control of both solution replacement and temperature in the microchannel, the temperature-dependent permeability of the oocyte membrane can be precisely characterized. Furthermore, the fertilization and developmental competence analysis post perfusion indicate that our approach does not compromise the physiological function of in vitro matured human oocytes. Collectively, we present the development of a novel sandwich structured microfluidic device based approach that allows on-chip characterization of the transport properties of human oocytes under innocuous osmotic shock or injury to the cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.