ArticleThe American journal of gastroenterology2017
Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities.
Article in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 4 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- Prevalence of CFTR Pathogenic Variants in Pancreatitis: A Systematic Review and Meta-Analysis.Clinical and translational gastroenterology · 2025Pooled it
- Burden of bone disease in chronic pancreatitis: A systematic review and meta-analysis.World journal of gastroenterology · 2023Pooled it
- Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis.Human genetics · 2022Pooled it
- Methods of Assessing Frailty in the Critically Ill: A Systematic Review of the Current Literature.Gerontology · 2022Pooled it
- Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model.Scientific reports · 2021Trial
- Current Status of Pancreatic Exocrine Insufficiency Diagnosis and Pancreatic Enzyme Replacement Therapy Implementation in Patients With Chronic Pancreatitis.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Pancrelipase Improves Symptoms of Exocrine Pancreatic Insufficiency and Health-Related Quality of Life in a Real-World Population of Patients with Chronic Pancreatitis.Digestive diseases and sciences · 2026Observational
- Rates of hospitalization pre- and post-total pancreatectomy with islet autotransplantation for patients with pancreatitis.Surgical endoscopy · 2026Article
- Comprehensive Assessment of Direct and Passive Smoking Across the Pancreatitis Spectrum.Pancreas · 2026Article
- Persistence of Mortality-Dominant Pancreatitis Burden Despite Declining Rates, 1990-2023: An Analysis of the Global Burden of Disease 2023 Study.Medical sciences (Basel, Switzerland) · 2026Article
- Static and dynamic quantitative sensory testing in chronic pancreatitis: Relation of pain sensitization to patient-reported outcomes and psychiatric comorbidities.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Personalizing treatment of pancreatitis-associated chronic pain: the need for an integrated omics approach.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Pancreatic exocrine insufficiency.EClinicalMedicine · 2026Review
- Article
- Mechanism-Based Management of Pain in Chronic Pancreatitis: An Integrated Narrative Review.Cureus · 2026Review
- Quality of life in recurrent acute pancreatitis and chronic pancreatitis: A prospective cross-sectional comparative bicentric study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Idiopathic chronic pancreatitis: clinical highlights.Therapeutic advances in gastroenterology · 2026Review
- Quality of life in children with chronic pancreatitis: An overlooked challenge.World journal of clinical pediatrics · 2025Review
- Health-related quality of life of unemployed individuals diagnosed with a mental illness: a cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Opioid dependence in patients with pain in chronic pancreatitis an emerging problem.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 17 institutions in 1 country.
Funding
Abstract
objectivesChronic pancreatitis (CP) has a profound independent effect on quality of life (QOL). Our aim was to identify factors that impact the QOL in CP patients.
methodsWe used data on 1,024 CP patients enrolled in the three NAPS2 studies. Information on demographics, risk factors, co-morbidities, disease phenotype, and treatments was obtained from responses to structured questionnaires. Physical and mental component summary (PCS and MCS, respectively) scores generated using responses to the Short Form-12 (SF-12) survey were used to assess QOL at enrollment. Multivariable linear regression models determined independent predictors of QOL.
resultsMean PCS and MCS scores were 36.7±11.7 and 42.4±12.2, respectively. Significant (P<0.05) negative impact on PCS scores in multivariable analyses was noted owing to constant mild-moderate pain with episodes of severe pain or constant severe pain (10 points), constant mild-moderate pain (5.2), pain-related disability/unemployment (5.1), current smoking (2.9 points), and medical co-morbidities. Significant (P<0.05) negative impact on MCS scores was related to constant pain irrespective of severity (6.8-6.9 points), current smoking (3.9 points), and pain-related disability/unemployment (2.4 points). In women, disability/unemployment resulted in an additional 3.7 point reduction in MCS score. Final multivariable models explained 27% and 18% of the variance in PCS and MCS scores, respectively. Etiology, disease duration, pancreatic morphology, diabetes, exocrine insufficiency, and prior endotherapy/pancreatic surgery had no significant independent effect on QOL.
conclusionsConstant pain, pain-related disability/unemployment, current smoking, and concurrent co-morbidities significantly affect the QOL in CP. Further research is needed to identify factors impacting QOL not explained by our analyses.
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