ArticleeLife2017
27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- Unexpected strong paramagnetism of hydrogels containing carbon-oxygen double bonds induced by calcium cations.Nature materials · 2026Article
- Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics.npj biomedical innovations · 2026Review
- High-Intensity Pulse Magnetic Fields Affect Redox Homeostasis and Survival Rate ofBiomolecules · 2025Article
- Ultra-high static magnetic fields altered the embryonic division and development in Caenorhabditis elegans via multipolar spindles.Journal of advanced research · 2025Article
- Targeted spleen modulation: a novel strategy for next-generation disease immunotherapy.Theranostics · 2025Review
- Effects of 16.8-22.0 T high static magnetic fields on the development of zebrafish in early fertilization.European radiology · 2024Article
- Cellular and Molecular Effects of Magnetic Fields.International journal of molecular sciences · 2024Review
- Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling Pathway.Research (Washington, D.C.) · 2024Article
- Magneto-mechanical stimulation modulates osteocyte fate via the ECM-integrin-CSK axis and wnt pathway.iScience · 2023Article
- The State of the Art of Natural Polymer Functionalized FeGels (Basel, Switzerland) · 2023Review
- Gradient Magnetic Field Accelerates Division ofCells · 2023Article
- Ultra-high static magnetic field induces a change in the spectrum but not frequency of DNA spontaneous mutations inFrontiers in plant science · 2023Article
- Intermittent F-actin Perturbations by Magnetic Fields Inhibit Breast Cancer Metastasis.Research (Washington, D.C.) · 2023Article
- Understanding the underlying mechanisms governing spindle orientation: How far are we from there?Journal of cellular and molecular medicine · 2022Review
- Magnetic field effects in biology from the perspective of the radical pair mechanism.Journal of the Royal Society, Interface · 2022Review
- Radical pairs may play a role in microtubule reorganization.Scientific reports · 2022Article
- Article
- An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth.Translational oncology · 2021Article
- A Static Magnetic Field Improves Iron Metabolism and Prevents High-Fat-Diet/Streptozocin-Induced Diabetes.Innovation (Cambridge (Mass.)) · 2021Article
- Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS-Mediated Oxidative Stress.Oxidative medicine and cellular longevity · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purified microtubules have been shown to align along the static magnetic field (SMF) in vitro because of their diamagnetic anisotropy. However, whether mitotic spindle in cells can be aligned by magnetic field has not been experimentally proved. In particular, the biological effects of SMF of above 20 T (Tesla) have never been reported. Here we found that in both CNE-2Z and RPE1 human cells spindle orients in 27 T SMF. The direction of spindle alignment depended on the extent to which chromosomes were aligned to form a planar metaphase plate. Our results show that the magnetic torque acts on both microtubules and chromosomes, and the preferred direction of spindle alignment relative to the field depends more on chromosome alignment than microtubules. In addition, spindle morphology was also perturbed by 27 T SMF. This is the first reported study that investigated the cellular responses to ultra-high magnetic field of above 20 T. Our study not only found that ultra-high magnetic field can change the orientation and morphology of mitotic spindles, but also provided a tool to probe the role of spindle orientation and perturbation in developmental and cancer biology.
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