Evidence map›Paper›PMID 28244271›Full record

Trial reportAutism research : official journal of the International Society for Autism Research2017

Parent-delivered early intervention in infants at risk for ASD: Effects on electrophysiological and habituation measures of social attention.

Emily J H Jones, Geraldine Dawson, Jean Kelly, Annette Estes, Sara Jane Webb

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Autism research : official journal of the International Society for Autism Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 6 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 6 syntheses or guidelines pooled it, 146 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Emily J H JonesCentre for Brain & Cognitive Development, Birkbeck, University of London, London, WC1E 7HX, United Kingdom.ORCID 0000-0001-5747-9540
Geraldine DawsonDepartment of Psychiatry and Behavioral Sciences, Duke University, Duke Center for Autism and Brain Development, 2608 Erwin Rd, Suite 300, Durham, North Carolina, 022705.
Jean KellySchool of Nursing, University of Washington, 1959 NE Pacific St., Seattle, Washington, 98195.
Annette EstesCenter on Human Development and Disability, University of Washington, Seattle, Washington, 98195.
Sara Jane WebbDepartment of Psychiatry & Behavioral Sciences, University of Washington, PO Box 5371, M/S CW8-6, Seattle, Washington, 98145.
Birkbeck, University of London · GBDuke University · USSeattle Children's Hospital · USSeattle Pacific University · USUniversity of Washington · US

Funding

UW Autism Center of ExcellenceP50HD055782 · NICHD · UNIVERSITY OF WASHINGTON · PI KING, BRYAN H · 2007 to 2011
$11.0M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI GARDEN, GWENN A · 2014 to 2019
$7.9M
Physiology of Attention and Regulation in Children with ASD and LDR01HD064820 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI WEBB, SARA JANE · 2010 to 2014
$1.7M
NICHD NIH HHS P50 HD055782NICHD NIH HHS R01 HD064820NICHD NIH HHS U54 HD083091
6 · The paper itself

Abstract

Prospective longitudinal studies of infants with older siblings with autism spectrum disorder (ASD) have indicated that differences in the neurocognitive systems underlying social attention may emerge prior to the child meeting ASD diagnostic criteria. Thus, targeting social attention with early intervention might have the potential to alter developmental trajectories for infants at high risk for ASD. Electrophysiological and habituation measures of social attention were collected at 6, 12, and 18 months in a group of high-risk infant siblings of children with ASD (N = 33). Between 9 and 11 months of age, infant siblings received a parent-delivered intervention, promoting first relationships (PFR), (n = 19) or on-going assessment without intervention (n = 14). PFR has been previously shown to increase parental responsivity to infant social communicative cues and infant contingent responding. Compared to infants who only received assessment and monitoring, infants who received the intervention showed improvements in neurocognitive metrics of social attention, as reflected in a greater reduction in habituation times to face versus object stimuli between 6 and 12 months, maintained at 18 months; a greater increase in frontal EEG theta power between 6 and 12 months; and a more comparable P400 response to faces and objects at 12 months. The high-risk infants who received the intervention showed a pattern of responses that appeared closer to the normative responses of two groups of age-matched low-risk control participants. Though replication is necessary, these results suggest that early parent-mediated intervention has the potential to impact the brain systems underpinning social attention in infants at familial risk for ASD. Autism Res 2017, 10: 961-972. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.

Indexed as

ParentsSocial BehaviorAttentionAutism Spectrum DisorderEarly Intervention, EducationalElectroencephalographyFemaleHabituation, PsychophysiologicHumansInfantMaleProspective StudiesRisk FactorsSiblingsASDautismhigh-riskinfantneurocognitivepromoting first relationshipssocial attention

Identifiers

PMID28244271
PMCPMC5993545
OpenAlexW2605961707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.