ArticleInternational wound journal2017
Improved detection of clinically relevant wound bacteria using autofluorescence image-guided sampling in diabetic foot ulcers.
Article in International wound journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04180748 (Survey of Diversity and Density on the Facial Bacteriome of Different Skin Types), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Survey of Diversity and Density on the Facial Bacteriome of Different Skin Types
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- The Clinical Utility of Autofluorescence Imaging for Bacterial Detection in Wounds: A Systematic Review.International wound journal · 2025Pooled it
- Systematic review and meta-analysis of diagnostic test accuracy in chronic wound's microbiology.International wound journal · 2024Pooled it
- Clinical Significance of Non-Invasive Skin Autofluorescence Measurement and AI Applications in Patients with Diabetic Foot Ulcers: A Scoping Review.Journal of personalized medicine · 2026Review
- Tetracycline Resistance Pattern Among Lymphatic Filariasis-Hyperendemic Communities in Southern Ghana: A Mixed-Method Approach.Health science reports · 2026Article
- Real-time detection and monitoring of bacteria in diabetic wounds using bacterial fluorescence.Frontiers in microbiology · 2026Article
- Clinical and Economic Evidence Supporting the Value of Fluorescence Imaging of Bacteria in Wound Care.Journal of market access & health policy · 2025Review
- Current and Future Directions in Fluorescence Imaging-Guided Debridement.Advances in wound care · 2025Review
- Prospective evaluation of the Moleculight i:X™ in the early detection of driveline infections.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Non-invasive techniques for wound assessment: A comprehensive review.International wound journal · 2024Review
- Wound management materials and technologies from bench to bedside and beyond.Nature reviews. Materials · 2024Article
- Determination of the Course of Cyan Fluorescence ofDiagnostics (Basel, Switzerland) · 2024Article
- How effective is simple mechanical wound debridement in reducing bacterial colonisation? Results of a prospective clinical study.International wound journal · 2024Article
- Lights, fluorescence, action-Influencing wound treatment plans including debridement of bacteria and biofilms.International wound journal · 2023Article
- Current and Future Developments in Wound Healing.Facial plastic surgery : FPS · 2023Article
- Advanced Wound Diagnostics: Toward Transforming Wound Care into Precision Medicine.Advances in wound care · 2022Review
- A soft intelligent dressing with pH and temperature sensors for early detection of wound infection.RSC advances · 2022Article
- Use of fluorescence imaging to optimize location of tissue sampling in hard-to-heal wounds.Frontiers in cellular and infection microbiology · 2022Article
- Detection of bacterial fluorescence from in vivo wound biofilms using a point-of-care fluorescence imaging device.International wound journal · 2021Article
- Diagnostics for Wound Infections.Advances in wound care · 2021Review
- Diagnosing Burn Wounds Infection: The Practice Gap & Advances with MolecuLight Bacterial Imaging.Diagnostics (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical wound assessment involves microbiological swabbing of wounds to identify and quantify bacterial species, and to determine microbial susceptibility to antibiotics. The Levine swabbing technique may be suboptimal because it samples only the wound bed, missing other diagnostically relevant areas of the wound, which may contain clinically significant bacteria. Thus, there is a clinical need to improve the reliability of microbiological wound sampling. To address this, a handheld portable autofluorescence (AF) imaging device that detects bacteria in real time, without contrast agents, was developed. Here, we report the results of a clinical study evaluating the use of real-time AF imaging to visualise bacteria in and around the wound bed and to guide swabbing during the clinical assessment of diabetic foot ulcers, compared with the Levine technique. We investigated 33 diabetic foot ulcers (n = 31 patients) and found that AF imaging more accurately identified the presence of moderate and/or heavy bacterial load compared with the Levine technique (accuracy 78% versus 52%, P = 0·048; adjusted diagnostic odds ratio 7·67, P < 0·00022 versus 3·07, P = 0·066) and maximised the effectiveness of bacterial load sampling, with no significant impact on clinical workflow. AF imaging may help clinicians better identify the wound areas with clinically significant bacteria, and maximise sampling of treatment-relevant pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.