ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017
Spinal Loading Patterns From Biomechanical Modeling Explain the High Incidence of Vertebral Fractures in the Thoracolumbar Region.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 144 citations in OpenAlex.
- Osteoporotic mid-thoracic vertebral body fractures: what are the differences compared to fractures of the lumbar spine?-a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Pooled it
- Free vitamin D correlate better with bone mineral density and thoracolumbar junction osteoporotic vertebral fractures than serum vitamin D.BMC musculoskeletal disorders · 2020Trial
- High-intensity exercise did not cause vertebral fractures and improves thoracic kyphosis in postmenopausal women with low to very low bone mass: the LIFTMOR trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Trial
- Thoracic Kyphosis on Chest CT Scans Is Associated With Incident Vertebral Fractures in Smokers.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Trial
- Article
- Spatial Investigation of Facet Joint Cartilage Properties Reveals Specific Structure-Function Relationships.JOR spine · 2026Article
- QCT-based geometric, densitometric, and biomechanical properties of the aging human thoracolumbar spine.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Comparable 2-year functional outcomes following vertebroplasty for thoracic and lumbar osteoporotic vertebral compression fractures: a retrospective cohort study.Asian spine journal · 2026Article
- Mid-thoracic predominance and region-specific risk factors for vertebral fractures in rheumatoid arthritis: a cross-sectional study.Clinical rheumatology · 2026Article
- Development and validation of a clinical risk stratification model for lumbar vertebral compression fractures in patients with lumbar disc herniation.Bone reports · 2026Article
- Biomechanical assessment of vertebral fracture risk incorporating the effect of paraspinal muscles.Medical & biological engineering & computing · 2026Article
- Concurrent Validity of Two Inertial Measurement Unit Pipelines for Estimating Lumbar and Thoracic Kinematics During Lifting Tasks.Sensors (Basel, Switzerland) · 2026Article
- Metastatic Spine Disease Alters Vertebral Load-To-Strength Ratios in Cancer Patients Compared to Healthy Individuals.JOR spine · 2026Article
- Reducing Complexity in Muscle-Tendon Kinematics Parameterization Improves Convergence Speed in Musculoskeletal Simulations.International journal for numerical methods in biomedical engineering · 2026Article
- Segment-specific prediction of vertebral collapse severity in osteoporotic fractures.Frontiers in endocrinology · 2026Article
- Insights into the Pathophysiology of Scheuermann's Kyphosis: From Structural Deformities to Genetic Predisposition and Underlying Signalling Pathways.Biomolecules · 2025Review
- Age-related bone loss in mouse lumbar vertebrae is affected by region, sex, and level: Implications for spinal loading and analysis methods.Bone reports · 2025Article
- Physiological and Anthropometric Factors Associated With Spine Loading Estimates From Imaging-Based Subject-Specific Musculoskeletal Models.JOR spine · 2025Article
- Spinal Anesthesia Using the Double-Needle Technique for Thoracolumbar Spine Fracture Surgery: A Case Series.Cureus · 2025Article
- Advantages of Combined Use of Claw Hooks and Sublaminar Wires as the Upper Foundation of Long Fixation from the Thoracic Spine to the Pelvis in Osteoporotic Cases: A Finite Element Analysis of Proximal Junction Stress.Spine surgery and related research · 2025Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Vertebral fractures occur most frequently in the mid-thoracic and thoracolumbar regions of the spine, yet the reasons for this site-specific occurrence are not known. Our working hypothesis is that the locations of vertebral fracture may be explained by the pattern of spine loading, such that during daily activities the mid-thoracic and thoracolumbar regions experience preferentially higher mechanical loading compared to other spine regions. To test this hypothesis, we used a female musculoskeletal model of the full thoracolumbar spine and rib cage to estimate the variation in vertebral compressive loads and associated factor-of-risk (load-to-strength ratio) throughout the spine for 119 activities of daily living, while also parametrically varying spine curvature (high, average, low, and zero thoracic kyphosis models). We found that nearly all activities produced loading peaks in the thoracolumbar and lower lumbar regions of the spine, but that the highest factor-of-risk values generally occurred in the thoracolumbar region of the spine because these vertebrae had lower compressive strength than vertebrae in the lumbar spine. The peaks in compressive loading and factor-of-risk in the thoracolumbar region were accentuated by increasing thoracic kyphosis. Activation of the multifidus muscle fascicles selectively in the thoracolumbar region appeared to be the main contributor to the relatively high vertebral compressive loading in the thoracolumbar spine. In summary, by using advanced musculoskeletal modeling to estimate vertebral loading throughout the spine, this study provides a biomechanical mechanism for the higher incidence of fractures in thoracolumbar vertebrae compared to other spinal regions. © 2017 American Society for Bone and Mineral Research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.