ReviewJournal of microbiology (Seoul, Korea)2017
The role of laboratory diagnostics in emerging viral infections: the example of the Middle East respiratory syndrome epidemic.
Review in Journal of microbiology (Seoul, Korea), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Development and clinical validation of a colorimetric isothermal assay for rapid detection of monkeypox virus.New microbes and new infections · 2026Article
- Scale-Up of COVID-19 Testing Services in NYC, 2020-2021: Lessons Learned to Maximize Reach, Equity and Timeliness.Journal of urban health : bulletin of the New York Academy of Medicine · 2024Article
- A comparative study of the policy response to COVID-19 in the ASEAN region: A dynamic simulated ARDL approach.PloS one · 2023Article
- A computational tool for trend analysis and forecast of the COVID-19 pandemic.Applied soft computing · 2021Article
- A network-based model to explore the role of testing in the epidemiological control of the COVID-19 pandemic.BMC infectious diseases · 2021Article
- Laboratory verification of an RT-PCR assay for SARS-CoV-2.Journal of clinical laboratory analysis · 2020Article
- Current diagnostic tools for coronaviruses-From laboratory diagnosis to POC diagnosis for COVID-19.Bioengineering & translational medicine · 2020Review
- Thoughts on What Chemists Can Contribute to Fighting SARS-CoV-2 - A Short Note on Hand Sanitizers, Drug Candidates and Outreach.Angewandte Chemie (International ed. in English) · 2020Article
- Laboratory testing of SARS-CoV, MERS-CoV, and SARS-CoV-2 (2019-nCoV): Current status, challenges, and countermeasures.Reviews in medical virology · 2020Review
- Qualitative and Quantitative Determination of MERS-CoV S1-Specific Antibodies Using ELISA.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Further Defining the Human Virome using NGS: Identification of Redondoviridae.Cell host & microbe · 2019Article
- Development and validation of different indirect ELISAs for MERS-CoV serological testing.Journal of immunological methods · 2019Article
- MERS coronavirus outbreak: Implications for emerging viral infections.Diagnostic microbiology and infectious disease · 2019Review
- International Biological Reference Preparations for Epidemic Infectious Diseases.Emerging infectious diseases · 2019Article
- An updated roadmap for MERS-CoV research and product development: focus on diagnostics.BMJ global health · 2019Article
- The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab.Acta crystallographica. Section D, Structural biology · 2018Article
- MERS, SARS and other coronaviruses as causes of pneumonia.Respirology (Carlton, Vic.) · 2018Review
- Inclusion of MERS-spike protein ELISA in algorithm to determine serologic evidence of MERS-CoV infection.Journal of medical virology · 2018Article
- An Opportunistic Pathogen Afforded Ample Opportunities: Middle East Respiratory Syndrome Coronavirus.Viruses · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapidly emerging infectious disease outbreaks place a great strain on laboratories to develop and implement sensitive and specific diagnostic tests for patient management and infection control in a timely manner. Furthermore, laboratories also play a role in real-time zoonotic, environmental, and epidemiological investigations to identify the ultimate source of the epidemic, facilitating measures to eventually control the outbreak. Each assay modality has unique pros and cons; therefore, incorporation of a battery of tests using traditional culture-based, molecular and serological diagnostics into diagnostic algorithms is often required. As such, laboratories face challenges in assay development, test evaluation, and subsequent quality assurance. In this review, we describe the different testing modalities available for the ongoing Middle East respiratory syndrome (MERS) epidemic including cell culture, nucleic acid amplification, antigen detection, and antibody detection assays. Applications of such tests in both acute clinical and epidemiological investigation settings are highlighted. Using the MERS epidemic as an example, we illustrate the various challenges faced by laboratories in test development and implementation in the setting of a rapidly emerging infectious disease. Future directions in the diagnosis of MERS and other emerging infectious disease investigations are also highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.