ArticleDocumenta ophthalmologica. Advances in ophthalmology2017
Comparing three different modes of electroretinography in experimental glaucoma: diagnostic performance and correlation to structure.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Contributions and future potential of animal models for geroscience research on sensory systems.GeroScience · 2025Review
- Eccentricity Dependency of Retinal Electrophysiological Deficits in People With Episodic Migraine.Investigative ophthalmology & visual science · 2024Article
- The diagnostic accuracy of photopic negative responses evoked by broadband and chromatic stimuli in a clinically heterogeneous population.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
- Utility of Light-Adapted Full-Field Electroretinogram ON and OFF Responses for Detecting Glaucomatous Functional Damage.Translational vision science & technology · 2023Article
- Silicone Oil-Induced Glaucomatous Neurodegeneration in Rhesus Macaques.International journal of molecular sciences · 2022Article
- Mimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres.Drug delivery · 2022Article
- The p-ERG spatial acuity in the biomedical pig under physiological conditions.Scientific reports · 2022Article
- Intereye structure-function relationship using photopic negative response in patients with glaucoma or glaucoma suspect.Scientific reports · 2022Article
- Photopic negative response recorded with RETeval system in eyes with optic nerve disorders.Scientific reports · 2022Article
- A Monoclonal Anti-HMGB1 Antibody Attenuates Neurodegeneration in an Experimental Animal Model of Glaucoma.International journal of molecular sciences · 2022Article
- Visual function tests for glaucoma practice - What is relevant?Indian journal of ophthalmology · 2022Review
- The role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma.Scientific reports · 2021Article
- Asymmetric Functional Impairment of ON and OFF Retinal Pathways in Glaucoma.Ophthalmology science · 2021Article
- Comparison of the Humphrey Field Analyzer and Photopic Negative Response of Focal Macular Electroretinograms in the Evaluation of the Relationship Between Macula Structure and Function.Frontiers in medicine · 2021Article
- A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma.International journal of molecular sciences · 2020Article
- The photopic negative response (PhNR): measurement approaches and utility in glaucoma.International ophthalmology · 2020Review
- Glaucoma - Next Generation Therapeutics: Impossible to Possible.Pharmaceutical research · 2018Review
- Consecutive unilateral recording of the two eyes affects dark-adapted ERG responses, when compared to simultaneous bilateral recording.Documenta ophthalmologica. Advances in ophthalmology · 2018Article
- Electroretinography in idiopathic intracranial hypertension: comparison of the pattern ERG and the photopic negative response.Documenta ophthalmologica. Advances in ophthalmology · 2018Article
- The Small Heat Shock Protein α-Crystallin B Shows Neuroprotective Properties in a Glaucoma Animal Model.International journal of molecular sciences · 2017Article
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Authors and funding
6 authors.
Funding
Abstract
purposeTo compare diagnostic performance and structure-function correlations of multifocal electroretinogram (mfERG), full-field flash ERG (ff-ERG) photopic negative response (PhNR) and transient pattern-reversal ERG (PERG) in a non-human primate (NHP) model of experimental glaucoma (EG).
methodsAt baseline and after induction of chronic unilateral IOP elevation, 43 NHP had alternating weekly recordings of retinal nerve fiber layer thickness (RNFLT) by spectral domain OCT (Spectralis) and retinal function by mfERG (7F slow-sequence stimulus, VERIS), ff-ERG (red 0.42 log cd-s/m
resultsStudy duration was 15 ± 8 months. At final follow-up, structural damage in EG eyes measured by RNFLT ranged from 9% above baseline (BL) to 58% below BL; 29/43 EG eyes (67%) and 0/43 of the fellow control eyes exhibited significant (>7%) loss of RNFLT from BL. Using raw parameter values, the largest A-ROC findings for mfERG were: HFC (0.82) and HFC:P1 (0.90); for ff-ERG: PhNR (0.90) and PhNR:B-wave (0.88) and for PERG: P50 (0.64) and N95 (0.61). A-ROC increased when data were expressed as % change from BL, but the pattern of results persisted. At 95% specificity, the diagnostic sensitivity of mfERG HFC:P1 ratio was best, followed by PhNR and PERG. The correlation to RNFLT was stronger for mfERG HFC (R = 0.65) than for PhNR (R = 0.59) or PERG N95 (R = 0.36), (p = 0.20, p = 0.0006, respectively). The PhNR flagged a few EG eyes at the final time point that had not been flagged by mfERG HFC or PERG.
conclusionsDiagnostic performance and structure-function correlation were strongest for mfERG HFC as compared with ff-ERG PhNR or PERG in NHP EG.
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