Evidence map›Paper›PMID 28243744›Full record

ArticleZeitschrift fur Rheumatologie2018

Toll-like receptor 7 gene single nucleotide polymorphisms and the risk for systemic lupus erythematosus: a case-control study.

I I Raafat, N El Guindy, R M H Shahin, L A Samy, R M El Refai

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Article in Zeitschrift fur Rheumatologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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  16. HighFrontiers in immunology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

I I RaafatDepartment of Clinical Pathology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
N El GuindyDepartment of Clinical Pathology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
R M H ShahinDepartment of Clinical Pathology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt. rasha.shaheen@kasralainy.edu.eg.
L A SamyDepartment of Clinical Pathology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
R M El RefaiDepartment of Rheumatology and Rehabilitation, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundToll-like receptors (TLRs) are a family of pattern-recognition receptors which play a role in eliciting innate/adaptive immune responses and developing chronic inflammation. So, the aim of this study was to analyze the effect of TLR7 gene single nucleotide polymorphisms (SNPs) rs3853839 and rs179019 on systemic lupus erythematosus (SLE) susceptibility and to assess their relations with various clinical and laboratory data of the patients.

methodsThis is a case-control study including 50 SLE female patients and 50 healthy controls. TLR7 rs3853839 and rs179019 genotyping was performed using real-time polymerase chain reaction (PCR) TaqMan-based allelic discrimination assay.

resultsRegarding rs3853839, there was a statistically significant difference in the distribution of the genotypes between SLE patients and the control group in our study (P = 0.009). A significant association was detected between TLR7 genotypes (rs385389) and lupus nephritis (p = 0.021). Regarding rs179019, there was no statistically significant difference in the distribution of the genotypes between SLE patients and the control group in our study (P = 0.271)

conclusionThis study revealed the plausible role of TLR7 rs3853839 SNP in SLE in Egyptian women.

Indexed as

Lupus Erythematosus, SystemicPolymorphism, Single NucleotideToll-Like Receptor 7AdultCase-Control StudiesEgyptFemaleGenetic Predisposition to DiseaseHumansYoung AdultTLR7 protein, humanToll-Like Receptor 7Lupus nephritisReal time polymerase chain reaction TaqMan-based allelic discrimination assaySingle nucleotide polymorphisms (SNPs)Systemic lupus erythematosus (SLE)Toll-like receptor 7 (TLR7)

Identifiers

PMID28243744
OpenAlexW2594067264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.