ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
Total 25-hydroxyvitamin D levels predict fracture risk: results from the 15-year follow-up of the Japanese Population-based Osteoporosis (JPOS) Cohort Study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 55 citations in OpenAlex.
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- Plasma 25-hydroxyvitamin D concentrations, vitamin D deficiency and mortality in community-dwelling Japanese adults.The British journal of nutrition · 2025Article
- Joint association of milk intake and blood 25(OH)D levels with fracture risk in postmenopausal women: 20-year follow-up data from the Japanese Population-Based Osteoporosis cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Effect of Vitamin D and Skeletal Muscle Mass on Prognosis of Patients with Diffuse Large B-Cell Lymphoma.Nutrients · 2024Article
- The impact of chronic obstructive pulmonary disease on bone strength.Journal of bone and mineral metabolism · 2024Review
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- Histomorphometric analysis of patients with femoral neck fracture and 25-hydroxyvitamin D deficiency: a cross-sectional study.Journal of bone and mineral metabolism · 2024Article
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- Effect of vitamin D deficiency on surgical outcomes of degenerative cervical myelopathy.North American Spine Society journal · 2023Article
- Prevalence and clinical outcomes of vitamin D deficiency among Japanese multiple myeloma patients: a single-center observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Observational
- Low bone mineral density and its related factors in adults with congenital heart disease in Vietnam: A cross-sectional study.Health science reports · 2022Article
- Evidence and suggestions for establishing vitamin D intake standards in Koreans for the prevention of chronic diseases.Nutrition research and practice · 2022Review
- Impact of serum vitamin D on the response and prognosis in breast cancer patients treated with neoadjuvant chemotherapy.Breast cancer (Tokyo, Japan) · 2022Article
- Lessons from the health policies for children during the pandemic in Japan.Frontiers in public health · 2022Review
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- Denosumab versus romosozumab for postmenopausal osteoporosis treatment.Scientific reports · 2021Article
- Real-world effects and adverse events of romosozumab in Japanese osteoporotic patients: A prospective cohort study.Bone reports · 2021Article
- Urinary pentosidine level is associated with grip strength and gait speed in community-dwelling adults: a cross-sectional study.BMC musculoskeletal disorders · 2021Article
- Insufficiency of B vitamins with its possible clinical implications.Journal of clinical biochemistry and nutrition · 2020Review
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We found that community-dwelling women with 25-hydroxyvitamin D levels <20 ng/mL compared to levels ≥20 ng/mL indicated increased risks for clinical, non-vertebral, and fragility fractures during 5 years. Furthermore, the increased risks of non-vertebral fractures remained significant in 10 and 15 years after adjusting for age and bone mineral density.
introductionWe examined whether total 25-hydroxyvitamin D (25[OH]D) levels are associated with fracture risk over 15 years in a Japanese female cohort.
methodsOf 1437 community-dwelling women aged ≥50 years in the baseline survey, 1236 provided information regarding fractures during a 15-year follow-up period. The analysis included 1211 women without early menopause or diseases affecting bone metabolism.
resultsOver 15 years, 269 clinical (224 non-vertebral, 149 fragility) fracture events were confirmed. Incidence rates categorized by 25(OH)D levels (<10, 10-20, 20-30, and ≥30 ng/mL) indicated a significant divergence for any clinical fractures in 5 years (log rank test p = 0.016) and for non-vertebral fractures in 5, 10, and 15 years (p < 0.001, p = 0.001, p = 0.017, respectively). Hazard ratios (HRs) for 25(OH)D levels <10 and 10-20 ng/mL compared to levels ≥30 ng/mL during 5 years indicated significances for clinical fractures (HR 4.93 with p = 0.009, HR 3.00 with p = 0.034) and for non-vertebral fractures (HR 6.55 with p = 0.005, HR 3.49 with p = 0.036). Those with levels <20 ng/mL compared to those with levels ≥20 ng/mL indicated significant increased risks for clinical fractures (HR 1.72 with p = 0.010), non-vertebral fractures (HR 2.45 with p < 0.001), and fragility fractures (HR 2.00 with p = 0.032) in 5 years. The HR of non-vertebral fractures for levels <20 ng/mL remained significant during 15 years (HR 1.42 with p = 0.012) after adjustment for age and femoral neck bone mineral density.
conclusionsLow 25(OH)D levels, especially <20 ng/mL, were associated with elevated fracture risks in Japanese women.
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