ReviewFrontiers in pediatrics2017
Cerebral Palsy-Trends in Epidemiology and Recent Development in Prenatal Mechanisms of Disease, Treatment, and Prevention.
Review in Frontiers in pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 107 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Conventionally Manufactured Lower Leg Orthoses and Modular Customized Lower Leg Orthoses (AFO 4.0) in Patients With Limited Neuromuscular Foot Function During Overground Walking
Aquatic Based Exercises Versus Mirror Therapy on Hand Dexterity and Strength in Hemiplegic Child
Lung Boost Trainer Versus Incentive Spirometer on Spiro-metric Indices in Post COVID-19 Hemiplegic Cerebral Palsy Children; Randomized Controlled Trial
Who cites it
107 citing papers in PubMed, 5 syntheses or guidelines pooled it, 361 citations in OpenAlex.
- Evaluating radiologic outcomes of surgical techniques used in foot valgus deformity of cerebral palsy patients: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Bisphosphonate use in children with cerebral palsy.The Cochrane database of systematic reviews · 2021Pooled it
- Effectiveness of exercise interventions for children with cerebral palsy: A systematic review and meta-analysis of randomized controlled trials.Journal of rehabilitation medicine · 2021Pooled it
- Pooled it
- Mechanically assisted walking training for walking, participation, and quality of life in children with cerebral palsy.The Cochrane database of systematic reviews · 2020Pooled it
- Learning ballet technique modulates the stretch reflex in students with cerebral palsy: case series.BMC neuroscience · 2024Trial
- Effect of core stabilization versus rebound therapy on balance in children with cerebral palsy.Acta neurologica Belgica · 2024Trial
- Game-Based Dual-Task Exercise Program for Children with Cerebral Palsy: Blending Balance, Visuomotor and Cognitive Training: Feasibility Randomized Control Trial.Sensors (Basel, Switzerland) · 2022Trial
- Potentiation of cord blood cell therapy with erythropoietin for children with CP: a 2 × 2 factorial randomized placebo-controlled trial.Stem cell research & therapy · 2020Trial
- Use of the Dyskinesia Impairment Scale in non-ambulatory dyskinetic cerebral palsy.Developmental medicine and child neurology · 2020Trial
- Standardizing early cerebral palsy detection in high-risk infants: reducing age at diagnosis through a quality improvement initiative.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Exploring the Psychosocial Impact on Families Caring for Children with Cerebral Palsy: A Qualitative Study in Saudi Arabia.Healthcare (Basel, Switzerland) · 2026Article
- Feasibility study of the assessment of upper limb function in children with Unilateral Cerebral Palsy using an end-effector robotic device.Journal of neuroengineering and rehabilitation · 2026Article
- A Reconciled Method for Evaluating the Cost-Effectiveness of Implementation Programmes: Illustrated by Quality Improvement Programmes to Increase the Uptake of Magnesium Sulphate in Preterm Births.Applied health economics and health policy · 2026Review
- Deep brain stimulation for the treatment of paediatric dystonia due to neuroanatomical abnormalities: a systematic review of efficacy and future perspectives.BMJ neurology open · 2026Article
- Predictors of dental caries in children and adolescents with cerebral palsy (CP): a cross-sectional analytical study in Malaysia.Translational pediatrics · 2025Article
- Social robots in cognitive and speech rehabilitation for children with cerebral palsy: a scoping review.Journal of neuroengineering and rehabilitation · 2025Review
- Serum Proteomics Reveals Diagnostic Biomarkers and Molecular Pathways in Cerebral Palsy.Nature communications · 2025Article
- Sprint-Intensity Arm Interval Training May Improve Cardiorespiratory Fitness and Cardiometabolic Health Among Children With Mobility Disabilities: Case Report.JMIR formative research · 2025Article
- Toward Home-Based Telerehabilitation for Cerebral Palsy Patients: A Qualitative Study on Feasibility, Barriers and Facilitators.Health science reports · 2025Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral palsy (CP) is the most common motor disability in childhood. This syndrome is the manifestation of intrauterine pathologies, intrapartum complications, and the postnatal sequel, especially among preterm neonates. A double hit model theory is proposed suggesting that an intrauterine condition along with intrapartum or postnatal insult lead to the development of CP. Recent reports demonstrated that treatment during the process of preterm birth such as magnesium sulfate and postnatal modalities such as cooling may prevent or reduce the prevalence of this syndrome. Moreover, animal models demonstrated that postnatal treatment with anti-inflammatory drugs coupled with nanoparticles may affect the course of the disease in pups with neuroinflammation. This review will describe the changes in the epidemiology of this disease, the underlying prenatal mechanisms, and possible treatments that may reduce the prevalence of CP and alter the course of the disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.