ArticlePeerJ2017
Tartrazine induces structural and functional aberrations and genotoxic effects
Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 107 citations in OpenAlex.
- Tartrazine-Induced Toxicity Is Attenuated by Naringenin in Wistar Rats: A Biochemical, Histological, and Behavioral Study.Nutrients · 2026Article
- Marvelous Characteristics of Hydroxyl-Functionalized Azo-Dye Polymers for Electrocatalytic Sensing: An Informative Review.ACS polymers Au · 2026Review
- Evaluation of the Role of Taurine in Mitigating the Deleterious Effects of Tartrazine on the Kidneys in Rats: Experimental Study.Turk patoloji dergisi · 2026Article
- Determination of the protective effect of curcumin against tartrazine-induced DNA damage and HSP 70 in the rat brain.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Toxic Effects of Tartrazine and the Protective Role of Curcumin on Liver Function and DNA Integrity in Male Rats.Food science & nutrition · 2025Article
- Toxicological Effects of Tartrazine Exposure: A Review of In Vitro and Animal Studies with Human Health Implications.Toxics · 2025Review
- The Impact of Tartrazine on DNA Methylation, Histone Deacetylation, and Genomic Stability in Human Cell Lines.Nutrients · 2025Article
- Article
- The food dye Tartrazine disrupts vascular formation both in zebrafish larvae and in human primary endothelial cells.Scientific reports · 2024Article
- Evaluation of the effect of tartrazine on the offspring rats in an in vivo experimental model.Food science & nutrition · 2024Article
- Review
- Determination of the effects of sunset yellow on mouse liver and pancreas using histological methods.Toxicology research · 2024Article
- Ginkgo biloba extract protects against tartrazine-induced testicular toxicity in rats: involvement of antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.Environmental science and pollution research international · 2024Article
- Tartrazine Modifies the Activity ofNutrients · 2023Article
- Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells.BMC pharmacology & toxicology · 2022Article
- Effects of Tartrazine on Some Sexual Maturation Parameters in Immature Female Wistar Rats.International journal of environmental research and public health · 2022Article
- Toxicological and Teratogenic Effect of Various Food Additives: An Updated Review.BioMed research international · 2022Review
- Oral administration of tartrazine (E102) accelerates the incidence and the development of 7,12-dimethylbenz(a) anthracene (DMBA)-induced breast cancer in rats.BMC complementary medicine and therapies · 2021Article
- Effect of tartrazine on digestive enzymatic activities: in vivo and in vitro studies.Toxicological research · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tartrazine is a synthetic organic azo dye widely used in food and pharmaceutical products. The current study aimed to evaluate the possible adverse effect of this coloring food additive on renal and hepatic structures and functions. Also, the genotoxic potential of tartrazine on white blood cells was investigated using comet assay. Twenty adult male Wistar rats were grouped into two groups of 10 each, control- and tartrazine-treated groups. The control group was administered orally with water alone. The experimental group was administered orally with tartrazine (7.5 mg/kg, b.wt.). Our results showed a marked increase in the levels of ALT, AST, ALP, urea, uric acid, creatinine, MDA and NO, and a decreased level of total antioxidants in the serum of rats dosed with tartrazine compared to controls. On the other hand, administration of tartrazine was associated with severe histopathological and cellular alterations of rat liver and kidney tissues and induced DNA damage in leucocytes as detected by comet assay. Taken together, the results showed that tartrazine intake may lead to adverse health effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.