Evidence map›Paper›PMID 28243505›Full record

ReviewNeurology. Clinical practice2017

Optimizing extended-release carbidopa/levodopa in Parkinson disease: Consensus on conversion from standard therapy.

Alberto J Espay, Fernando L Pagan, Benjamin L Walter, John C Morgan, Lawrence W Elmer, Cheryl H Waters, Pinky Agarwal, Rohit Dhall, William G Ondo, Kevin J Klos and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology. Clinical practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Levodopa/carbidopa/entacapone for the treatment of early Parkinson's disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Medical Management and Prevention of Motor Complications in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Extended-release oral capsule of carbidopa-levodopa in Parkinson disease.Therapeutic advances in neurological disorders · 2018
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alberto J EspayUniversity of Cincinnati (AJE), OH; Georgetown University Hospital (FLP), Washington, DC; Case Western Reserve University (BLW), Cleveland, OH; Medical College of Georgia (JCM), Augusta University; University of Toledo College of Medicine (LWE), OH; Columbia University (CHW), New York, NY; Evergreen Hospital Medical Center (PA), Kirkland, WA; Parkinson's Institute and Clinical Center (RD), Sunnyvale, CA; Methodist Neurological Institute (WGO), Houston, TX; The Movement Disorder Clinic of Oklahoma (KJK), Tulsa; and Coastal Neurological Medical Group, Inc. (DES), La Jolla, CA.
Fernando L PaganUniversity of Cincinnati (AJE), OH; Georgetown University Hospital (FLP), Washington, DC; Case Western Reserve University (BLW), Cleveland, OH; Medical College of Georgia (JCM), Augusta University; University of Toledo College of Medicine (LWE), OH; Columbia University (CHW), New York, NY; Evergreen Hospital Medical Center (PA), Kirkland, WA; Parkinson's Institute and Clinical Center (RD), Sunnyvale, CA; Methodist Neurological Institute (WGO), Houston, TX; The Movement Disorder Clinic of Oklahoma (KJK), Tulsa; and Coastal Neurological Medical Group, Inc. (DES), La Jolla, CA.
Benjamin L WalterUniversity of Cincinnati (AJE), OH; Georgetown University Hospital (FLP), Washington, DC; Case Western Reserve University (BLW), Cleveland, OH; Medical College of Georgia (JCM), Augusta University; University of Toledo College of Medicine (LWE), OH; Columbia University (CHW), New York, NY; Evergreen Hospital Medical Center (PA), Kirkland, WA; Parkinson's Institute and Clinical Center (RD), Sunnyvale, CA; Methodist Neurological Institute (WGO), Houston, TX; The Movement Disorder Clinic of Oklahoma (KJK), Tulsa; and Coastal Neurological Medical Group, Inc. (DES), La Jolla, CA.
John C MorganUniversity of Cincinnati (AJE), OH; Georgetown University Hospital (FLP), Washington, DC; Case Western Reserve University (BLW), Cleveland, OH; Medical College of Georgia (JCM), Augusta University; University of Toledo College of Medicine (LWE), OH; Columbia University (CHW), New York, NY; Evergreen Hospital Medical Center (PA), Kirkland, WA; Parkinson's Institute and Clinical Center (RD), Sunnyvale, CA; Methodist Neurological Institute (WGO), Houston, TX; The Movement Disorder Clinic of Oklahoma (KJK), Tulsa; and Coastal Neurological Medical Group, Inc. (DES), La Jolla, CA.
Lawrence W ElmerUniversity of Cincinnati (AJE), OH; Georgetown University Hospital (FLP), Washington, DC; Case Western Reserve University (BLW), Cleveland, OH; Medical College of Georgia (JCM), Augusta University; University of Toledo College of Medicine (LWE), OH; Columbia University (CHW), New York, NY; Evergreen Hospital Medical Center (PA), Kirkland, WA; Parkinson's Institute and Clinical Center (RD), Sunnyvale, CA; Methodist Neurological Institute (WGO), Houston, TX; The Movement Disorder Clinic of Oklahoma (KJK), Tulsa; and Coastal Neurological Medical Group, Inc. (DES), La Jolla, CA.
Cheryl H WatersUniversity of Cincinnati (AJE), OH; Georgetown University Hospital (FLP), Washington, DC; Case Western Reserve University (BLW), Cleveland, OH; Medical College of Georgia (JCM), Augusta University; University of Toledo College of Medicine (LWE), OH; Columbia University (CHW), New York, NY; Evergreen Hospital Medical Center (PA), Kirkland, WA; Parkinson's Institute and Clinical Center (RD), Sunnyvale, CA; Methodist Neurological Institute (WGO), Houston, TX; The Movement Disorder Clinic of Oklahoma (KJK), Tulsa; and Coastal Neurological Medical Group, Inc. (DES), La Jolla, CA.
Pinky AgarwalUniversity of Cincinnati (AJE), OH; Georgetown University Hospital (FLP), Washington, DC; Case Western Reserve University (BLW), Cleveland, OH; Medical College of Georgia (JCM), Augusta University; University of Toledo College of Medicine (LWE), OH; Columbia University (CHW), New York, NY; Evergreen Hospital Medical Center (PA), Kirkland, WA; Parkinson's Institute and Clinical Center (RD), Sunnyvale, CA; Methodist Neurological Institute (WGO), Houston, TX; The Movement Disorder Clinic of Oklahoma (KJK), Tulsa; and Coastal Neurological Medical Group, Inc. (DES), La Jolla, CA.
Rohit DhallUniversity of Cincinnati (AJE), OH; Georgetown University Hospital (FLP), Washington, DC; Case Western Reserve University (BLW), Cleveland, OH; Medical College of Georgia (JCM), Augusta University; University of Toledo College of Medicine (LWE), OH; Columbia University (CHW), New York, NY; Evergreen Hospital Medical Center (PA), Kirkland, WA; Parkinson's Institute and Clinical Center (RD), Sunnyvale, CA; Methodist Neurological Institute (WGO), Houston, TX; The Movement Disorder Clinic of Oklahoma (KJK), Tulsa; and Coastal Neurological Medical Group, Inc. (DES), La Jolla, CA.
William G OndoUniversity of Cincinnati (AJE), OH; Georgetown University Hospital (FLP), Washington, DC; Case Western Reserve University (BLW), Cleveland, OH; Medical College of Georgia (JCM), Augusta University; University of Toledo College of Medicine (LWE), OH; Columbia University (CHW), New York, NY; Evergreen Hospital Medical Center (PA), Kirkland, WA; Parkinson's Institute and Clinical Center (RD), Sunnyvale, CA; Methodist Neurological Institute (WGO), Houston, TX; The Movement Disorder Clinic of Oklahoma (KJK), Tulsa; and Coastal Neurological Medical Group, Inc. (DES), La Jolla, CA.
Kevin J KlosUniversity of Cincinnati (AJE), OH; Georgetown University Hospital (FLP), Washington, DC; Case Western Reserve University (BLW), Cleveland, OH; Medical College of Georgia (JCM), Augusta University; University of Toledo College of Medicine (LWE), OH; Columbia University (CHW), New York, NY; Evergreen Hospital Medical Center (PA), Kirkland, WA; Parkinson's Institute and Clinical Center (RD), Sunnyvale, CA; Methodist Neurological Institute (WGO), Houston, TX; The Movement Disorder Clinic of Oklahoma (KJK), Tulsa; and Coastal Neurological Medical Group, Inc. (DES), La Jolla, CA.
Dee E SilverUniversity of Cincinnati (AJE), OH; Georgetown University Hospital (FLP), Washington, DC; Case Western Reserve University (BLW), Cleveland, OH; Medical College of Georgia (JCM), Augusta University; University of Toledo College of Medicine (LWE), OH; Columbia University (CHW), New York, NY; Evergreen Hospital Medical Center (PA), Kirkland, WA; Parkinson's Institute and Clinical Center (RD), Sunnyvale, CA; Methodist Neurological Institute (WGO), Houston, TX; The Movement Disorder Clinic of Oklahoma (KJK), Tulsa; and Coastal Neurological Medical Group, Inc. (DES), La Jolla, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewTo help clinicians optimize the conversion of a patient's Parkinson disease pharmacotherapy from immediate-release carbidopa/levodopa (IR CD/LD) to an extended-release formulation (ER CD/LD). RECENT

findingsEleven movement disorders specialists achieved consensus positions on the modification of trial-based conversion guidelines to suit individual patients in clinical practice. SUMMARY: Because the pharmacokinetics of ER CD/LD differ from those of IR CD/LD, modification of dosage and dosing frequency are to be expected. Initial regimens may be based on doubling the patient's preconversion levodopa daily dosage and choosing a division of doses to address the patient's motor complications, e.g., wearing-off (warranting a relatively high ER CD/LD dose, possibly at a lower frequency than for IR CD/LD) or dyskinesia (warranting a relatively low dose, perhaps at an unchanged frequency). Patients should know that the main goal of conversion is a steadier levodopa clinical response, even if dosing frequency is unchanged.

Identifiers

PMID28243505
PMCPMC5310207

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.