Evidence map›Paper›PMID 28243459›Full record

ArticleBJPsych open2017

Neurometabolic abnormalities in schizophrenia and depression observed with magnetic resonance spectroscopy at 7 T.

Reggie Taylor, Elizabeth A Osuch, Betsy Schaefer, Nagalingam Rajakumar, Richard W J Neufeld, Jean Théberge, Peter C Williamson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJPsych open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 7 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 7 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Leveraging ultra-high field (7T) MRI in psychiatric research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  9. Article
  10. Review
  11. Metabolomic Biomarkers in Anxiety Disorders.International journal of molecular sciences · 2020
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Reggie Taylor, PhD, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada.
Elizabeth A Osuch, MD, Department of Medical Biophysics; Department of Psychiatry, University of Western Ontario, London, Ontario, Canada.
Betsy Schaefer, BSc, Department of Psychiatry, University of Western Ontario, London, Ontario, Canada.
Nagalingam Rajakumar, PhD, Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.
Richard W J Neufeld, PhD, Department of Psychology; Department of Neuroscience, University of Western Ontario, London, Ontario, Canada.
Jean Théberge, PhD, Department of Medical Biophysics, Department of Psychiatry, Department of Medical Imaging, University of Western Ontario, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada; St. Joseph's Health Care, Department of Diagnostic Imaging, London, Ontario, Canada.
Peter C Williamson, MD, Department of Medical Biophysics, Department of Psychiatry, University of Western Ontario, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada.
Western University · CALawson Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExamining neurometabolic abnormalities in critical brain areas in schizophrenia and major depressive disorder (MDD) may help guide future pharmacological interventions including glutamate-modulating treatments.

aimsTo measure metabolite concentrations within the anterior cingulate cortex (ACC) and thalamus of people with schizophrenia and people with MDD.

methodsSpectra were acquired from 16 volunteers with schizophrenia, 17 with MDD and 18 healthy controls using magnetic resonance spectroscopy on a 7 Tesla scanner.

resultsIn the thalamus, there were lower glycine concentrations in the schizophrenia group relative to control (

conclusionThese results support the glutamatergic theory of schizophrenia and indicate a potential glycine deficiency in the thalamus. In addition, reduced DECLARATION OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.

Identifiers

PMID28243459
PMCPMC5288640
OpenAlexW2583374520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.