Evidence map›Paper›PMID 28243231›Full record

ArticleFrontiers in immunology2017

IL-10-Producing CD1d

Ying Chen, Chao Li, Yiping Lu, Huiying Zhuang, Weijia Gu, Bo Liu, Fangwei Liu, Jinkai Sun, Bo Yan, Dong Weng and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. The Role of TLR7 and TLR9 in the Pathogenesis of Systemic Sclerosis.International journal of molecular sciences · 2024
    Article
  7. Article
  8. Review
  9. The role of inflammation in silicosis.Frontiers in pharmacology · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ying ChenDivision of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China.
Chao LiDivision of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China.
Yiping LuDivision of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China.
Huiying ZhuangDivision of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China.
Weijia GuDivision of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China.
Bo LiuDivision of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China.
Fangwei LiuDivision of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China.
Jinkai SunDepartment of Respiratory Medicine, Shenyang No. 9 Hospital , Shenyang , China.
Bo YanDepartment of Respiratory Medicine, Shenyang No. 9 Hospital , Shenyang , China.
Dong WengDivision of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China; Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Jie ChenDivision of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China.
China Medical University · CNWuhan No.9 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silicosis is characterized by chronic lung inflammation and fibrosis, which are extremely harmful to human health. The pathogenesis of silicosis involves uncontrolled immune processes. Evidence supports that regulatory B cells (Bregs) produce negative regulatory cytokines, such as IL-10, which can negatively regulate immune responses in inflammation and autoimmune diseases. Our previous study found that IL-10-producing B cells were involved in the development of silica-induced lung inflammation and fibrosis of mice. However, little is known about the role of Bregs in silicosis patients (SP). In this study, we found that serum concentrations of IL-10 were significantly increased in SP by using protein array screening. We further determined that the frequency of IL-10-producing CD1d

Indexed as

IL-10immune homeostasisregulatory B cellsregulatory T cellssilicosis patientsTh1/Th2 polarization

Identifiers

PMID28243231
PMCPMC5303715
OpenAlexW2586146757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.