ArticleJournal of pain research2017
A comparison of the postoperative analgesic efficacy between epidural and intravenous analgesia in major spine surgery: a meta-analysis.
Article in Journal of pain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Postoperative epidural analgesia versus systemic analgesia for thoraco-lumbar spine surgery in children.The Cochrane database of systematic reviews · 2019Pooled it
- Comparison of efficacy between combined periarticular and incisional injections versus periarticular injection alone of bupivacaine for pain control after total knee arthroplasty: A prospective randomized controlled trial.Acta orthopaedica et traumatologica turcica · 2020Trial
- Epidural and intravenous patient-controlled analgesia and the timing of epidural catheter removal after posterior lumbar interbody fusion: a retrospective cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Thromboembolic complications were not different between intravenous and epidural analgesia after unilateral knee arthroplasty under neuraxial anesthesia: a propensity-score matched analysis.Perioperative medicine (London, England) · 2026Article
- Continuous Low-dose Epidural Morphine and Ketamine Analgesia Improves Quality of Recovery after Major Lumbar Spine Surgery: A Randomised Controlled Trial.Turkish journal of anaesthesiology and reanimation · 2025Article
- Retrograde Surgical Placement of a Thoracic Epidural Catheter in a Patient Undergoing Combined Thoracic and Spinal Surgery.International medical case reports journal · 2025Article
- Article
- The impact of magnesium on shivering incidence in cardiac surgery patients: A systematic review.Heliyon · 2024Article
- Inter-Semispinalis Plane Block Versus General Anesthesia for Postoperative Analgesia in Posterior Cervical Spine Surgery: A Randomized Controlled Trial.Anesthesiology and pain medicine · 2024Article
- Accelerate postoperative management after scoliosis surgery in healthy and impaired children: intravenous opioid therapy versus epidural therapy.Archives of orthopaedic and trauma surgery · 2023Article
- Injectable electrospun fiber-hydrogel composite sequentially releasing clonidine and ropivacaine for prolonged and walking regional analgesia.Theranostics · 2022Article
- Predictive Risk Factors Associated With Increased Opioid Use Among Patients Undergoing Elective Spine Surgery.International journal of spine surgery · 2020Article
- Effects of periarticular injection on analgesic effects and NSAID use in total knee arthroplasty and total hip arthroplasty.Clinics (Sao Paulo, Brazil) · 2017Article
- Anesthetic considerations in spine surgery: What orthopaedic surgeon should know!Journal of clinical orthopaedics and traumaReview
- Comparison of two different doses of dexmedetomidine for continuous epidural analgesia for lower limb surgeries: A randomized double-blind study.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative analgesia remains a challenge for orthopedic surgeons. The aim of this meta-analysis is to compare the efficacy of epidural analgesia (EA) and intravenous patient-controlled analgesia (IV-PCA) following major spine surgery. We searched electronic databases, including the PubMed, EMBASE, Ovid and Cochrane databases, for randomized controlled trials (RCTs) published before June 2016. The quality of the included trials was assessed using the Cochrane risk-of-bias tool. Random effects models were used to estimate the standardized mean differences (SMDs) and relative risks (RRs), with the corresponding 95% confidence intervals (CI). Subgroup analyses stratified by the type of epidural-infused medication and epidural delivery were also performed. A total of 17 trials matched the inclusion criteria and were chosen for the following meta-analysis. Overall, EA provided significantly superior analgesia, higher patient satisfaction and decreased overall opioid consumption compared with IV-PCA following major spine surgery. Additionally, no differences were found in the side effects associated with these two methods of analgesia. Egger's and Begg's tests showed no significant publication bias. We suggest that EA is superior to IV-PCA for pain management after major spine surgery. More large-scale, high-quality trials are needed to verify these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.