ArticleInternational journal of chronic obstructive pulmonary disease2017
A cross-sectional survey of night-time symptoms and impact of sleep disturbance on symptoms and health status in patients with COPD.
Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Systematic Review of Physical Activity, Sedentary Behaviour and Sleep Among Adults Living with Chronic Respiratory Disease in Low- and Middle-Income Countries.International journal of chronic obstructive pulmonary disease · 2022Pooled it
- The quality of life in Chinese population with chronic non-communicable diseases according to EQ-5D-3L: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Pooled it
- Once-daily single-inhaler versus twice-daily multiple-inhaler triple therapy in patients with COPD: lung function and health status results from two replicate randomized controlled trials.Respiratory research · 2020Trial
- Supine hyperinflation and expiratory flow limitation are associated with respiratory arousals and nocturnal hypoventilation in COPD.BMJ open respiratory research · 2025Observational
- Perturbation of the circadian clock in chronic diseases involving organ fibrosis.The Journal of clinical investigation · 2025Review
- Associations between widowhood status/duration, depression, and cognitive function among community-dwelling Indians age 60 years or older: Exploration of sex and residential factors.Social psychiatry and psychiatric epidemiology · 2025Article
- Insights into associations between Life's essential 8 and lung function from NHANES data.Scientific reports · 2025Article
- Predicting sleep quality among college students during COVID-19 lockdown using a LASSO-based neural network model.BMC public health · 2025Article
- Poor sleep quality in chronic obstructive pulmonary disease.La Tunisie medicale · 2025Article
- Development and validation of a predictive model for acute exacerbation in chronic obstructive pulmonary disease patients with comorbid insomnia.Frontiers in medicine · 2025Article
- Latent profiles and influencing factors of sleep quality in patients with chronic obstructive pulmonary disease.Frontiers in medicine · 2025Article
- The effect of expiratory flow limitation on supine persistent hyperinflation in COPD: a prospective observational study.ERJ open research · 2024Article
- Article
- Exploring the Link between Social Support and Patient-Reported Outcomes in Chronic Obstructive Pulmonary Disease Patients: A Cross-Sectional Study in Primary Care.Healthcare (Basel, Switzerland) · 2024Article
- Sex Differences in the Associations Between Chronic Diseases and Insomnia Symptoms Among Older Adults in India.Nature and science of sleep · 2024Article
- Quality of life in patients with chronic respiratory failure on home mechanical ventilation.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- The impact of impaired sleep quality on symptom change and future exacerbation of chronic obstructive pulmonary disease.Respiratory research · 2023Article
- Content Validation of Patient-Reported Sleep Measures and Development of a Conceptual Model of Sleep Disturbance in Patients with Moderate-to-Severe, Uncontrolled Asthma.Patient related outcome measures · 2023Article
- Sleep Quality and Self-Reported Symptoms of Anxiety and Depression Are Associated with Physical Activity in Patients with Severe COPD.International journal of environmental research and public health · 2022Article
- The Burden of Nocturnal Symptoms in Patients with Chronic Obstructive Pulmonary Disease: Results of a Real-World Survey in the USA.Pulmonary therapy · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSleep disturbance has been termed the forgotten dimension of chronic obstructive pulmonary disease (COPD), but it is clinically important as most patients are affected. This study examined the incremental burden of illness associated with sleep disturbance in COPD, with reference to health status and disease impact, and the degree of concordance between physicians and patients in reporting night-time COPD symptoms.
methodsReal-world data from >2,500 patients with COPD consulting for routine care were derived from respiratory Disease-Specific Programs conducted in Europe, the USA, and China. Night-time COPD symptom burden was assessed from patient and physician perspectives. Patients completed the Jenkins Sleep Evaluation Questionnaire (JSEQ), COPD assessment test (CAT), and EuroQol five-dimension questionnaire (EQ-5D). A regression approach was used to analyze the relationship between sleep disturbance (JSEQ score) and health status (EQ-5D score), adjusting for confounding variables.
resultsFrequency of night-time symptoms was high and was higher when reported by patients than physicians (69.7% and 65.7%, respectively). According to the JSEQ, 73.3% of patients had trouble falling asleep, 75.3% experienced night-time awakenings, 70.6% had trouble staying asleep, and 67.7% woke after a usual amount of sleep feeling worn out. Over half (52.7%) of patients received maintenance treatment where night-time symptom relief was stated by the physician as a treatment aim. A one unit increase in JSEQ score was associated with increased CAT score (0.7 units in Europe and the USA; 0.2 units in China). Sleep disturbance was significantly associated with worse health status (odds ratio [OR]: 1.27, 95% confidence interval [CI]: 1.18, 1.36,
conclusionsNight-time symptoms and sleep disturbance are common among patients with COPD, and sleep disturbance has a detrimental impact on COPD symptoms and health status.
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Registered trials
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