Evidence map›Paper›PMID 28242826›Full record

ArticlePhysiological reports2017

Gender differences in hypoxic acclimatization in cyclooxygenase-2-deficient mice.

Kui Xu, Xiaoyan Sun, Girriso F Benderro, Constantinos P Tsipis, Joseph C LaManna

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kui XuDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio kxx@case.edu.
Xiaoyan SunDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.
Girriso F BenderroDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.
Constantinos P TsipisDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.
Joseph C LaMannaDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.
Case Western Reserve University · US

Funding

BRAIN VASCULAR AND METABOLIC ADAPTATION TO HYPOXIAR01NS038632 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI LAMANNA, JOSEPH CHARLES · 2000 to 2014
$4.7M
NINDS NIH HHS R01 NS038632
6 · The paper itself

Abstract

The aim of this study was to determine the effect of cyclooxygenase-2 (COX-2) gene deletion on the adaptive responses during prolonged moderate hypobaric hypoxia. Wild-type (WT) and COX-2 knockout (KO) mice of both genders (3 months old) were exposed to hypobaric hypoxia (~0.4 ATM) or normoxia for 21 days and brain capillary densities were determined. Hematocrit was measured at different time intervals; brain hypoxia-inducible factor -1

Indexed as

Sex CharacteristicsAcclimatizationAngiopoietin-2AnimalsBrainCyclooxygenase 2ErythropoietinFemaleHypoxiaHypoxia-Inducible Factor 1, alpha SubunitKidneyMaleMiceMice, KnockoutSex FactorsVascular Endothelial Growth Factor AAngiopoietin-2Cyclooxygenase 2ErythropoietinHypoxia-Inducible Factor 1, alpha SubunitVascular Endothelial Growth Factor ACapillary densityhypoxia‐induced angiogenesishypoxic adaptationprolonged hypoxiasex differences

Identifiers

PMID28242826
PMCPMC5328777
OpenAlexW2593044975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.